Metagenomics for Ocular Inflammation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

36 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-12

Study Completion Date

2026-07-12

Brief Summary

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The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available standard testing. For many people with ocular inflammation, no cause is ever found for their disease. In some cases, an infection or infectious trigger is suspected, but currently available tests are inadequate. Metagenomic sequencing can identify almost every globally known infection (bacteria, virus, fungi, parasites) in a sample. Therefore, it has the potential to identify an infection that has caused or triggered ocular inflammation, and as a consequence may help to identify specific treatments. It has the potential to improve our understanding of how to diagnose and treat people with this problem. This study will allow us to test the technique that has been previously optimised for brain infections, on ocular fluids. Participants will be 18 years of age or over and have active ocular inflammation which is suspected to be due to an infection, or an autoimmune process which has been triggered by an infection, but identification of this infection has not been possible using the investigations available as part of standard NHS care. Participants will be identified by the treating clinical team as requiring a sample of fluid from inside of the eye, and some of this fluid will be sent for metagenomic sequencing alongside standard testing. This study will be conducted at Moorfields Eye Hospital, London and will last for approximately a year. Participants will undergo additional non-invasive ocular imaging on the day of their clinic visit, but will not have to attend any additional research visits.

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Detailed Description

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Conditions

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Uveitis Aqueous Humor Infection

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with ocular inflammation presumed to be infectious or para-infectious

Patients with Ocular Inflammation undergoing Metagenomics on Aqueous Humour

Ocular Imaging

Intervention Type DIAGNOSTIC_TEST

Ocular imaging with anterior segment OCT, laser flare photometry, confocal microscopy and colour fundus photography.

Metagenomic sequencing of aqueous humor

Intervention Type DIAGNOSTIC_TEST

Metagenomic Sequencing on aqueous humor surplus to diagnostic requirements

Interventions

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Ocular Imaging

Ocular imaging with anterior segment OCT, laser flare photometry, confocal microscopy and colour fundus photography.

Intervention Type DIAGNOSTIC_TEST

Metagenomic sequencing of aqueous humor

Metagenomic Sequencing on aqueous humor surplus to diagnostic requirements

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. 18 years of age or older with the capacity to consent
2. Standard of care has not determined a clinical diagnosis
3. Active ocular inflammation with risk of visual loss
4. Clinically suspected infectious or para-infectious cause of ocular inflammation