A Randomized Controlled Trial Comparing the Efficacy of Commercial Weight Management Programs

NCT ID: NCT06972277

Last Updated: 2026-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

459 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-14

Study Completion Date

2026-01-09

Brief Summary

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The study compares the effectiveness of three commercial weight management programs. The primary outcome is absolute and percentage weight change at 12-weeks.

Detailed Description

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Conditions

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Obesity and Overweight

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Commercial weight management program 1

Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program.

Group Type EXPERIMENTAL

Commercial weight management program

Intervention Type BEHAVIORAL

Participants will receive evidence-based behavioral / lifestyle support from a commercial weight management program.

Commercial weight management program 2

Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program.

Group Type EXPERIMENTAL

Commercial weight management program

Intervention Type BEHAVIORAL

Participants will receive evidence-based behavioral / lifestyle support from a commercial weight management program.

Commercial weight management program 3

Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program.

Group Type EXPERIMENTAL

Commercial weight management program

Intervention Type BEHAVIORAL

Participants will receive evidence-based behavioral / lifestyle support from a commercial weight management program.

Interventions

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Commercial weight management program

Participants will receive evidence-based behavioral / lifestyle support from a commercial weight management program.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* BMI ≥27 kg/m²
* Own a bodyweight scale that they can weigh themselves with during the study
* Willing and able to comply with study protocol
* Capable of providing informed consent
* Able to read and write in English
* Willing to be randomized
* Willing to sign a Non Disclosure Agreement

Exclusion Criteria

* Pregnant, lactating, or plans to become pregnant in the next 6 months
* Previous bariatric surgery or planned bariatric surgery during the study period
* Major surgery within the past 6 months or plans to have surgery during the study period
* Participation in the previous 3 months or current participation in a structured behavioral weight loss program
* Participation in another structured weight loss program during the study period (i.e., the next 3 months)
* Communication needs that would render them unable to understand the study and/or intervention materials
* Current or previous history of anorexia or bulimia nervosa
* Engagement with vomiting or laxative use within the last 28 days with the aim of controlling their shape or weight
* Currently taking anti-obesity medications, planning to take anti-obesity medications in the next 6 months, or previously taken anti-obesity medications in the previous 3 months
* Weight loss of ≥ 5 kg (11 lb) in the previous 6 months
* Self-reported diagnosis of severe depression, bipolar disorder, substance abuse, or psychosis
* Participants who are involved in any other research studies at this time
* Untreated thyroid disease or any changes (type or dose) in thyroid medication in last 6 months
* Chronic/inflammatory gastrointestinal disorders (irritable bowel syndrome is acceptable)
* History of heart problems (e.g., angina, bypass surgery, myocardial infarction, etc.) within previous 6 months
* Diagnosis of type 1 or type 2 diabetes
* Presence of implanted cardiac defibrillator or pacemaker
* History of cancer within past 5 years or current treatment for cancer
* Hospitalization for psychiatric disorders during the last 12 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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WW International Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Jamil Alkhaddo

Medical Director, Clinical Development

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jamil Alkhaddo, MD

Role: PRINCIPAL_INVESTIGATOR

WW International Inc

Locations

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WW International, Inc

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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The ACE Study

Identifier Type: -

Identifier Source: org_study_id

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