Development and Application of Intervention Program to Improve Mental Health and Quality of Life of Solid Tumor Survivors and Caregivers

NCT ID: NCT06969742

Last Updated: 2025-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-27

Study Completion Date

2028-12-31

Brief Summary

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The research team will assess the psychological abilities like cognitive(how you think and figure things out) and psycho-social(the well-being at the intersection of the internal workings and external experience) functions of young patients who are diagnosed with solid tumor and their primary caregivers. After assessing the psychological abilities, the research team will provide counseling and educational sessions developed by the team. The sessions are provided on a 1:1 basis to each of the participants to verify whether the sessions helped to improve the quality of life, including mental health.

Detailed Description

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This study targets pediatric and adolescent cancer patients who are in the acute-transitional survival period(during cancer treatment to within 2 years of treatment end date) and their primary caregivers. Evaluation on the cognitive and psycho-social functions of pediatric and adolescent patients and their primary caregivers are conducted beforehand. Subsequently, the patients and caregivers are provided with psycho-education and psychological intervention program developed by the research team. The program is provided on a 1:1 basis to each subject to verify its effectiveness in improving quality of life, including mental health.

For patients and caregivers starting or undergoing cancer treatment, the purpose and information of the study will be informed when they visit the research participating institution: National Cancer Center or Seoul National University Hospital. For patients and caregivers who have completed the cancer treatment and the treatment end date is within 2 years, the research team will screen the patients during the relevant period. The purpose and information of the study will be provided during outpatient treatment. The research involves vulnerable subjects such as minors, therefore under the consent of the caregiver(a legal guardian), consent form with age-appropriate explanations of the study will be provided.

Before beginning the session, the patients will carry out neurocognitive assessments. The assessments includes Intelligence (Korean Wechsler Intelligence Scale for Children 4th and 5th Edition/Korean Wechsler Intelligence Scale 4th Edition), Memory(Rey-Kim Memory Test), Executive Function(Kims Frontal-Executive Neuropsychological Test), Attention(Children's Color Trails Test, Advanced Test of Attention / Trail Making Test, Continuous Performance Test), and Visual-Motor Integration 6th Edition.

During the pre-evaluation and orientation session, a counseling structure is establish for the next sessions of the program. The psycho-education and psychological intervention program is developed by comprehensively reflecting patient and caregiver interviews, previous research, and research team opinions. The program integrates and applies various evidence based theories, such as mindfulness theory, solution-focused theory, resilience theory, and family intervention theory. Consisting of core modules and elective modules, the program varies whether the patient is starting or undergoing cancer treatment, or have completed the cancer treatment. For patients and caregivers starting or undergoing cancer treatment, 4 core sessions and 1 elective session(selected out of the provided 3 topics) will be conducted. For patients and caregivers whose treatment end date is within 2 years, 7 core sessions and 3 elective sessions will be conducted. Every session is a 1:1 basis except for the family session, which the patient and the caregiver will participate together. Each session will last approximately 40-50 minutes, and conducted 1-2 times a week. The psycho-education and psychological intervention program is provided by the participating research institution and research team who have participated in the development of the program: National Cancer Center, Seoul National University Hospital, and Tree and Forest Psychological Counseling Center. Each of the institution has an assigned clinical psychologist who will conduct the sessions of the program. The program can be conducted in person or remotely. For patients starting or undergoing treatment, an independent counseling room will be provided by the research participating institution conducting the cancer treatment. For those who live far away or have difficulty in traveling to participate the program, an online video platform (ZOOM) can be utilized, or the sessions can be conducted on an individual location requested by the research subject under agreement.

To verify the effectiveness of the program, the patients and caregivers will carry out psychological questionnaires 2\~3 times, depending on the group they are randomized in. For patients and caregivers starting or undergoing treatment and randomized into experimental group(Experimental Group\_In cancer treatment) will carry out the questionnaires 2 times: before beginning the session, and after the core session(4th session). For patients and caregivers starting or undergoing treatment but randomized into control group(Control Group\_In cancer treatment) will also carry out the questionnaires 2 times: after enrollment, and 4 weeks after the enrollment. For patients and caregivers whose treatment end date is within 2 years and randomized into experimental group(Experimental Group\_After cancer treatment) will carry out the questionnaires 3 times: before beginning the session, after the core session(7th session), and after the end of the whole session(10th session). For patients and caregivers whose treatment end date is within 2 years but randomized into control group(Control Group\_After cancer treatment) will also carry out the questionnaires 3 times: after enrollment, 7 weeks after the enrollment, and 10 weeks after the enrollment.

Conditions

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Pediatric Solid Tumors

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Experimental Group_After cancer treatment

Patients and primary caregivers(guardians) who have completed the cancer treatment and the treatment end date is within 2 years, and who are randomized into a experimental group.

This group undergoes 10 sessions of psycho-education and psychological intervention(7 core sessions and 3 elective sessions) which last approximately 40 to 50 minutes per session.

The experimental group will carry out psychological questionnaires three times: before beginning the session, after the core session(7th session), and after the end of the whole session(10th session).

Psychological questionnaires includes emotional behavior evaluation tools for patients and caregivers and family evaluation tools for caregivers.

The experimental group will carry out neurocognitive assessments before beginning the session.

Group Type EXPERIMENTAL

Psycho-education and Psychological intervention_After cancer treatment

Intervention Type OTHER

The intervention program consists of Psycho-education and Psychological intervention that includes cognitive behavioral therapy sessions and interventions for patients and caregivers.

It integrates and applies various evidence-based theories; mindfulness theory, solution-focused theory, resilience theory, and family intervention theory.

The intervention is divided into two sessions; core sessions and elective sessions. The after cancer treatment group undergoes 7 core sessions and 3 elective sessions, a total of 10 sessions.

The sessions are conducted 1:1, either face-to-face or remote, and 1 to 2 times a week, approximately 50 minutes per session.

Control Group_After cancer treatment

Patients and primary caregivers(guardians) who have completed the cancer treatment and the treatment end date is within 2 years, and who are randomized into a wait list control group.

This group waits for 7 weeks before engaging in the counseling sessions. This group undergoes the same sessions as the experimental\_after cancer treatment group(10 sessions).

The wait list group will carry out psychological questionnaires three times: after the enrollment, 7 weeks after the enrollment, and 10 weeks after the enrollment.

Psychological questionnaires includes emotional behavior evaluation tools for patients and caregivers and family evaluation tools for caregivers.

The wait list group will carry out neurocognitive assessments after the enrollment.

Group Type OTHER

Psycho-education and Psychological intervention_After cancer treatment

Intervention Type OTHER

The intervention program consists of Psycho-education and Psychological intervention that includes cognitive behavioral therapy sessions and interventions for patients and caregivers.

It integrates and applies various evidence-based theories; mindfulness theory, solution-focused theory, resilience theory, and family intervention theory.

The intervention is divided into two sessions; core sessions and elective sessions. The after cancer treatment group undergoes 7 core sessions and 3 elective sessions, a total of 10 sessions.

The sessions are conducted 1:1, either face-to-face or remote, and 1 to 2 times a week, approximately 50 minutes per session.

Experimental Group_In cancer treatment

Patients and primary caregivers(guardians) going through cancer treatment and who are randomized into a experimental group.

This group undergoes 5 sessions of psycho-education and psychological intervention(4 core sessions and 1 elective sessions) which last approximately 40 to 50 minutes per session.

The experimental group will carry out psychological questionnaires two times: before beginning the session, and after the core session(4th session).

Psychological questionnaires includes emotional behavior evaluation tools for patients and caregivers and family evaluation tools for caregivers.

The experimental group will carry out neurocognitive assessments before beginning the session.

Group Type EXPERIMENTAL

Psycho-education and Psychological intervention_In cancer treatment

Intervention Type OTHER

The intervention program consists of Psycho-education and Psychological intervention that includes cognitive behavioral therapy sessions and interventions for patients and caregivers.

It integrates and applies various evidence-based theories; mindfulness theory, solution-focused theory, resilience theory, and family intervention theory.

The intervention is divided into two sessions; core sessions and elective sessions.

The intervention is divided into two sessions; core sessions and elective sessions. The in cancer treatment group undergoes 4 core sessions and 1 elective session, which is selected out of the given three topics, a total of 5 sessions.

The sessions are conducted 1:1, either face-to-face or remote, and 1 to 2 times a week, approximately 50 minutes per session.

Control Group_In cancer treatment

Patients and primary caregivers(guardians) going through cancer treatment and who are randomized into a wait list control group.

This group waits for 4 weeks before engaging in the counseling sessions. This group undergoes the same sessions as the experimental\_in cancer treatment group(5 sessions on psycho-education and psychological intervention; 4 core sessions and 1 elective sessions).

The wait list group will carry out psychological questionnaires two times: after the enrollment, and 4 weeks after the enrollment.

Psychological questionnaires includes emotional behavior evaluation tools for patients and caregivers and family evaluation tools for caregivers.

The wait list group will carry out neurocognitive assessments after the enrollment.

Group Type OTHER

Psycho-education and Psychological intervention_In cancer treatment

Intervention Type OTHER

The intervention program consists of Psycho-education and Psychological intervention that includes cognitive behavioral therapy sessions and interventions for patients and caregivers.

It integrates and applies various evidence-based theories; mindfulness theory, solution-focused theory, resilience theory, and family intervention theory.

The intervention is divided into two sessions; core sessions and elective sessions.

The intervention is divided into two sessions; core sessions and elective sessions. The in cancer treatment group undergoes 4 core sessions and 1 elective session, which is selected out of the given three topics, a total of 5 sessions.

The sessions are conducted 1:1, either face-to-face or remote, and 1 to 2 times a week, approximately 50 minutes per session.

Interventions

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Psycho-education and Psychological intervention_After cancer treatment

The intervention program consists of Psycho-education and Psychological intervention that includes cognitive behavioral therapy sessions and interventions for patients and caregivers.

It integrates and applies various evidence-based theories; mindfulness theory, solution-focused theory, resilience theory, and family intervention theory.

The intervention is divided into two sessions; core sessions and elective sessions. The after cancer treatment group undergoes 7 core sessions and 3 elective sessions, a total of 10 sessions.

The sessions are conducted 1:1, either face-to-face or remote, and 1 to 2 times a week, approximately 50 minutes per session.

Intervention Type OTHER

Psycho-education and Psychological intervention_In cancer treatment

The intervention program consists of Psycho-education and Psychological intervention that includes cognitive behavioral therapy sessions and interventions for patients and caregivers.

It integrates and applies various evidence-based theories; mindfulness theory, solution-focused theory, resilience theory, and family intervention theory.

The intervention is divided into two sessions; core sessions and elective sessions.

The intervention is divided into two sessions; core sessions and elective sessions. The in cancer treatment group undergoes 4 core sessions and 1 elective session, which is selected out of the given three topics, a total of 5 sessions.

The sessions are conducted 1:1, either face-to-face or remote, and 1 to 2 times a week, approximately 50 minutes per session.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Those between the ages of 10 and 24, and diagnosed with pediatric solid tumor, who are undergoing treatment or survivors who have completed the treatment and the treatment end date is within 2 years.
* Parent or legal guardian who is a primary caregiver to children and adolescent patient of acute-transitional phase.
* Those whose cognitive ability is capable of verbal counseling and who agrees to the evaluation assessment.

Exclusion Criteria

* Those who disagree to participate as a research subject.
* Those whose psycho-emotional state requires professional treatment or medical conditions precludes intervention.
* Those undergoing treatment and children and adolescent survivors of acute-transitional phase, whose prior intelligence assessment FSIQ score is less than 70. However, if the GAI score is 70 or higher, participation is possible after the principal investigator's interview, with linguistic competence taken into consideration.

Elimination Criteria:

* Those who withdraw consent of this research.
* Those who have difficulty participating due to worsening of disease or decease of patient.
Minimum Eligible Age

10 Years

Maximum Eligible Age

24 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role collaborator

Tree and Forest Psychological Counseling Center

UNKNOWN

Sponsor Role collaborator

National Cancer Center, Korea

OTHER_GOV

Sponsor Role lead

Responsible Party

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Joo-Young Kim

Principal Investigator, Senior Researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Principal Investigator

Role: PRINCIPAL_INVESTIGATOR

National Cancer Center

Co-Investigator

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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National Cancer Center

Goyang-si, Gyonggi-do, South Korea

Site Status RECRUITING

Tree and Forest Psychological Counseling Center

Seoul, Seoul, South Korea

Site Status ACTIVE_NOT_RECRUITING

Seoul National University Children's Hospital

Seoul, Seoul, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Principal Investigator

Role: CONTACT

+82) 031-902-1724

Facility Contacts

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Principal Investigator

Role: primary

+82 031)-920-1724

Co-Invertigator

Role: primary

+82) 02-2072-1215

Other Identifiers

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RS-2023-CC139231

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

NCC2024-0006

Identifier Type: -

Identifier Source: org_study_id

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