Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty
NCT ID: NCT06966518
Last Updated: 2025-05-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2025-05-12
2025-10-01
Brief Summary
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Detailed Description
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Ketamine is a non-competitive N-Methyl D-Aspartate (NMDA) receptor antagonist that works by blocking the NMDA receptors in the central and peripheral nervous systems.
Magnesium sulfate is also an antagonist for NMDA receptor that has been evaluated in several studies and showed that Mg sulfate decreased consumption of postoperative opioids.
Ketamine and magnesium sulfate have different sites of action on NMDA receptors, so their combination may produce a synergistic effect on NMDA receptors, resulting in more control of postoperative pain and more sparing of consumption of opioids.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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KM Group
Patients will receive a bolus of 0.5 mg/kg of ketamine given over a period of ten minutes followed by a constant infusion of 0.25 mg/kg/hr and a bolus dose of 30 mg/kg of magnesium sulfate during a 10-minute period followed by a continuous infusion of 9 mg/kg/hr.
Ketamine and Magnesium Sulfate
Patients will receive a bolus of 0.5 mg/kg of ketamine given over a period of ten minutes followed by a constant infusion of 0.25 mg/kg/hr and a bolus dose of 30 mg/kg of magnesium sulfate during a 10-minute period followed by a continuous infusion of 9 mg/kg/hr.
Control group
Patients will receive saline 0.9% as a control group.
Saline 0.9%
Patients will receive saline 0.9% as a control group.
Interventions
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Ketamine and Magnesium Sulfate
Patients will receive a bolus of 0.5 mg/kg of ketamine given over a period of ten minutes followed by a constant infusion of 0.25 mg/kg/hr and a bolus dose of 30 mg/kg of magnesium sulfate during a 10-minute period followed by a continuous infusion of 9 mg/kg/hr.
Saline 0.9%
Patients will receive saline 0.9% as a control group.
Eligibility Criteria
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Inclusion Criteria
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status I - II.
* Scheduled for rhinoplasty under general anesthesia.
Exclusion Criteria
* Drug addiction.
* Cardiovascular disease.
* Respiratory disease, renal, liver, metabolic and neurological disease.
* Pregnancy or breast feeding.
* Asthma.
18 Years
65 Years
ALL
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Sarah Ahmed
Lecturer of Anesthesia, Intensive care, and pain management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Locations
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Ain Shams University
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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36264PR1199/4/25
Identifier Type: -
Identifier Source: org_study_id
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