Quantifying Ocular Surface Aberrations After Tear Film Interventions
NCT ID: NCT06966349
Last Updated: 2025-10-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
12 participants
INTERVENTIONAL
2025-06-10
2025-12-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
DOUBLE
Study Groups
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Experimental: Systane Complete / Senofilcon A/ Somofilcon A
On the first day of the study, one drop of Systane Complete will be instilled in each eye. On the second day of the study, senofilcon A will be worn in both eyes. On the third day of the study, somofilcon A will be worn in both eyes.
Systane Complete Preservative-Free
One drop of Systane Complete Preservative Free will be instilled in each eye.
Higher order aberrations assessed before and after instillation.
Senofilcon A
Daily disposable silicone hydrogel contact lenses indicated for myopia or hyperopia.
Higher order aberrations assessed before and after instillation.
Somofilcon A
Daily disposable silicone hydrogel contact lenses indicated for myopia or hyperopia.
Higher order aberrations assessed before and after instillation.
Experimental: Systane Complete/ Somofilcon A/ Senofilcon A
On the first day of the study, one drop of Systane Complete will be instilled in each eye. On the second day of the study, somofilcon A will be worn in both eyes. On the third day of the study, senofilcon A will be worn in both eyes.
Systane Complete Preservative-Free
One drop of Systane Complete Preservative Free will be instilled in each eye.
Higher order aberrations assessed before and after instillation.
Senofilcon A
Daily disposable silicone hydrogel contact lenses indicated for myopia or hyperopia.
Higher order aberrations assessed before and after instillation.
Somofilcon A
Daily disposable silicone hydrogel contact lenses indicated for myopia or hyperopia.
Higher order aberrations assessed before and after instillation.
Interventions
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Systane Complete Preservative-Free
One drop of Systane Complete Preservative Free will be instilled in each eye.
Higher order aberrations assessed before and after instillation.
Senofilcon A
Daily disposable silicone hydrogel contact lenses indicated for myopia or hyperopia.
Higher order aberrations assessed before and after instillation.
Somofilcon A
Daily disposable silicone hydrogel contact lenses indicated for myopia or hyperopia.
Higher order aberrations assessed before and after instillation.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Have signed the information consent letter.
3. Are willing and able to follow instructions and maintain the appointment schedule.
4. Habitually wear spherical soft contact lenses (no multifocal lens, no toric lens wear or extended (overnight) wear).
5. Have a vertex-corrected refractive astigmatism of no more than 0.75D in each eye.
6. Achieve a best corrected visual acuity of 0.00 logMAR or better in each eye.
7. Agree to wear the study contact lenses for at least 6 hours.
8. Have clear corneas (e.g. no central scars).
9. Have no active ocular disease or inflammation.
Exclusion Criteria
2. Have worn any rigid contact lenses in the past 30 days.
3. Have been diagnosed with irregular cornea (e.g., keratoconus, etc.).
4. Have any known active ocular condition, disease, and/or infection.\*
5. Have a systemic or ocular condition that, in the opinion of the investigator, may affect a study outcome variable.
6. Have a known sensitivity to the diagnostic sodium fluorescein to be used in the study.
7. Have undergone refractive error surgery.
8. Are a member of the study team for this study, i.e. are listed on the delegation log for this study.
17 Years
ALL
Yes
Sponsors
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University of Waterloo
OTHER
Responsible Party
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Principal Investigators
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Lyndon Jones, PhD, DSc, FCOptom
Role: PRINCIPAL_INVESTIGATOR
Centre for Ocular Research & Education
Locations
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Centre for Ocular Research & Education
Waterloo, Ontario, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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47100
Identifier Type: -
Identifier Source: org_study_id
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