Rebound Pain After Peripheral Nerve Blocks in Total Knee Arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-21

Study Completion Date

2025-12-25

Brief Summary

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This prospective observational study aims to determine the incidence and clinical impact of rebound pain after peripheral nerve blocks in patients undergoing total knee arthroplasty. Rebound pain is defined as a sudden, severe pain (NRS ≥7) emerging after block resolution. Primary outcome is the incidence of rebound pain; secondary outcomes include pain severity, rescue analgesia use, nausea, vomiting, sleep quality, and patient satisfaction.

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Detailed Description

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Conditions

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Total Knee Arthroplasty Postoperative Pain Rebound Pain Peripheral Nerve Block Pain Management

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age between 18 and 70 years
* ASA physical status I to III
* Scheduled for elective unilateral total knee arthroplasty under spinal anesthesia
* Peripheral nerve block (PNB) planned as part of multimodal analgesia
* Ability to understand and provide written informed consent
* Willingness and ability to complete the postoperative pain diary

Exclusion Criteria

* Known allergy or hypersensitivity to local anesthetics
* Contraindication to regional anesthesia
* ASA physical status IV or higher
* Neurological or psychiatric disorders interfering with study participation or pain reporting
* Use of anticoagulants or presence of coagulopathy
* Use of medications that may alter pain perception or rebound pain response
* Local infection at the block site
* Emergency surgeries
* Inability or unwillingness to complete the postoperative pain diary or follow-up

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No