Computational Cardiac Imaging Analysis to Guide Ventricular Tachycardia Ablation Procedures (AI-VT)

NCT ID: NCT06964152

Last Updated: 2025-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-01

Study Completion Date

2034-12-31

Brief Summary

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The purpose of this study is to evaluate the clinical outcomes (clinical efficacy and safety) of using supplemental non-invasive computational ECG and cardiac imaging analysis tools to help guide ablation of ventricular tachycardia.

Detailed Description

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Conditions

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Ventricular Tachycardia (VT) Premature Ventricular Contraction (PVC) Ventricular Fibrillation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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VT ablation guided by supplemental non-invasive computational imaging analysis

The electrophysiologist performing the standard-of-care VT ablation will have access to supplemental arrhythmia targeting/localization information provided by computational non-invasive ECG and/or cardiac CT imaging analysis

Group Type EXPERIMENTAL

Computational electrocardiography and cardiac computed tomography mapping

Intervention Type DIAGNOSTIC_TEST

Use of non-invasive computational ECG and cardiac CT models to localize arrhythmia origins

Interventions

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Computational electrocardiography and cardiac computed tomography mapping

Use of non-invasive computational ECG and cardiac CT models to localize arrhythmia origins

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Age between 21 and 100
2. Evidence of ventricular tachycardia on ECG, telemetry or by CIED interrogation.
Minimum Eligible Age

21 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Gordon Ho

Principal Investigator, Cardiac Electrophysiology Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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UC San Diego Health

La Jolla, California, United States

Site Status

Countries

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United States

References

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Krummen DE, Villongco CT, Ho G, Schricker AA, Field ME, Sung K, Kacena KA, Martinson MS, Hoffmayer KS, Hsu JC, Raissi F, Feld GK, McCulloch AD, Han FT. Forward-Solution Noninvasive Computational Arrhythmia Mapping: The VMAP Study. Circ Arrhythm Electrophysiol. 2022 Sep;15(9):e010857. doi: 10.1161/CIRCEP.122.010857. Epub 2022 Sep 7.

Reference Type BACKGROUND
PMID: 36069189 (View on PubMed)

Other Identifiers

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171964

Identifier Type: -

Identifier Source: org_study_id

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