Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

NCT ID: NCT06963463

Last Updated: 2025-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-06

Study Completion Date

2027-07-31

Brief Summary

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The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep difficulties are a promising target for youth with suicidal thoughts and behavior to focus on as a prevention measure. We aim to increase intervention acceptability and impact by adapting it for the adolescent populations at highest risk for suicidal thoughts and behavior. The research project will compare Transdiagnostic Sleep and Circadian Intervention (TranS-C), an evidence based, modularized intervention that targets a range of sleep difficulties to a treatment as usual or control condition including providing weekly sleep feedback reports from data entered into a daily sleep diary and from wearing a sleep sensing, actigraphy watch. Participants in both conditions (TranS-C vs. Sleep Feedback) will wear an actigraphy sleep watch that monitors sleep, and complete daily sleep diaries via smartphone or email. Participants in the TranS-C condition will also wear bright light (BL) and blue blocking glasses each day as well as attend weekly or biweekly sessions with a Sleep Therapist. The sleep therapist will review sleep feedback during sessions.

Detailed Description

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This study will adapt TranS-C+BL for at-risk adolescents using health equity-informed implementation science methods.

This randomized trial will enroll 75 youth aged 12-18 at risk for STB and clinically significant sleep difficulties identified in primary care. The randomization that this study uses is a 2:1 allocation to compare TranS-C+BL Sleep Feedback vs. Sleep Feedback Alone.

Conditions

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Sleep Disturbance Sleep Depression Suicide

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Sleep Feedback

Participants receive an actigraphy watch to track their sleep and activity levels and complete a daily sleep diary; sleep feedback graphs show participants their actigraphy watch and sleep diary data on demand.

Group Type EXPERIMENTAL

Sleep Feedback

Intervention Type BEHAVIORAL

Participants are provided with an actigraphy watch that is used to monitor their sleep and activity throughout the day and complete a sleep diary daily. Along with wearing the watch they also will be provided access to their actigraphy and sleep diary graphs that document their data.

TranS-C + Sleep Feedback

Participants will attend 6-8 TranS-C sessions with a Sleep therapist. Participants will also wear bright light glasses in the morning and blue light blocking glasses in the evening throughout the intervention.

Group Type EXPERIMENTAL

TranS-C

Intervention Type BEHAVIORAL

This intervention includes participants attending 6-8 sessions with a Sleep Therapist.

Sleep Feedback

Intervention Type BEHAVIORAL

Participants are provided with an actigraphy watch that is used to monitor their sleep and activity throughout the day and complete a sleep diary daily. Along with wearing the watch they also will be provided access to their actigraphy and sleep diary graphs that document their data.

Interventions

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TranS-C

This intervention includes participants attending 6-8 sessions with a Sleep Therapist.

Intervention Type BEHAVIORAL

Sleep Feedback

Participants are provided with an actigraphy watch that is used to monitor their sleep and activity throughout the day and complete a sleep diary daily. Along with wearing the watch they also will be provided access to their actigraphy and sleep diary graphs that document their data.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Adolescents (12-18)
* Current moderate to severe depression as measured by the PHQ-9M with a total score of greater than or equal to 11
* Current clinically significant sleep disturbance measured by the PHQ-9-M sleep item greater than or equal to 2.
* English language fluency and literacy sufficient to engage in study protocol.

Exclusion Criteria

* Evidence of obstructive sleep apnea,
* Evidence of restless legs syndrome
* Evidence of psychosis
* Evidence of bipolar disorder
* Evidence of a developmental disability precluding comprehension of study procedures per electronic health record and eligibility screening.
Minimum Eligible Age

12 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Children's Hospital of Philadelphia

OTHER

Sponsor Role collaborator

University of Oregon

OTHER

Sponsor Role collaborator

National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

University of Pittsburgh

OTHER

Sponsor Role lead

Responsible Party

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Tina R Goldstein

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tina Goldstein, Ph.D

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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Childrens Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Brandie George-Milford, MA

Role: CONTACT

412-246-5629

Beth Hafer

Role: CONTACT

412-999-5051

Facility Contacts

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Jami Young, PhD

Role: primary

215-590-7555

Tina Goldstein

Role: primary

412-246-5604

Other Identifiers

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P50MH115838

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY22040040

Identifier Type: -

Identifier Source: org_study_id

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