Effects of Chestnuts on Postprandial Glycaemic Response

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-06

Study Completion Date

2026-04-30

Brief Summary

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Nut consumption is known to improve health outcomes, such as reducing the risk of chronic diseases like diabetes, cognitive impairment, and cardiovascular diseases. While most research has focused on walnuts and almonds, there is limited information on the health benefits of chestnuts. Chestnuts are unique among tree nuts due to their high starch and fibre content, along with vitamins E and C, minerals (potassium, phosphorus, magnesium), and polyphenols.

Evidence from in vitro and animal studies suggests that chestnuts may positively affect health by regulating the gut microbiome, lowering the glycaemic index, and providing antioxidant benefits. The food industry is also exploring new uses for chestnuts, particularly in gluten-free products, due to their nutritional benefits and good taste. Nonetheless, no research has investigated the health effects of chestnuts in humans. By addressing this gap in the literature, the study may lead to the development of new dietary strategies for improved health outcomes.

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Detailed Description

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Conditions

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Postprandial Glycemia Insulin Resistance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

The participants will be requested to attend 2 morning visits to the research centre to receive one of the test meals. These meals will be isocaloric with or without the addition of chestnut flour. The order in which they undertake the two test visits will be randomised.

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Control meal

Participants will receive an isocaloric baked meal without chestnut flour.

Group Type PLACEBO_COMPARATOR

Control meal

Intervention Type OTHER

Participants will receive an isocaloric baked meal without chestnut flour.

Chestnut meal

Participants will receive an isocaloric baked meal with chestnut flour.

Group Type EXPERIMENTAL

Chestnut meal

Intervention Type OTHER

Participants will receive an isocaloric baked meal with chestnut flour.

Interventions

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Chestnut meal

Participants will receive an isocaloric baked meal with chestnut flour.

Intervention Type OTHER

Control meal

Participants will receive an isocaloric baked meal without chestnut flour.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults 18-65 years old
* Available to attend two testing sessions at the research facility

Exclusion Criteria

* Allergy to nuts and/or gluten,
* BMI\<18.5 or ≥30 kg/m2,
* Fasting glucose \>5.6 mmol/L, presence of diabetes and/or taking anti-diabetic medication
* Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery,
* Smoker,
* Cardiovascular disease
* Pregnant or breastfeeding women
* Presence of implanted cardiac defibrillator

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes