Effects of Surgical Correction of Nasal Obstruction on Oxygen Uptake and Ventilation Volume

NCT ID: NCT06957262

Last Updated: 2025-05-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-01-01
• Study Completion Date: 2020-01-15

Brief Summary

This retrospective study aims to evaluate the effect of surgical correction of nasal obstruction on aerobic performance parameters in male athletes aged 20-32 years. The main questions it aims to answer are:

• Does nasal obstruction surgery impact running economy and ventilation during exercise?
• Does it affect oxygen consumption during submaximal running efforts?

Researchers will retrospectively compare male athletes who underwent nasal obstruction surgery (experimental group) to matched athletes without nasal obstruction (control group) to assess changes in respiratory function and exercise performance.

Participants were assessed by:

• Acoustic rhinometry to measure nasal cavity dimensions.
• The Nasal Obstruction Symptom Evaluation (NOSE) scale and Epworth Sleepiness Scale (ESS) to evaluate nasal obstruction symptoms and daytime sleepiness.
• Incremental treadmill exercise tests to collect data on gas exchange, oxygen consumption, ventilation, and running economy before and after the surgical intervention (or across a similar time period for the control group).

Conditions

Nasal Obstruction; Septoplasty Surgeries; Athletic Performance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Athletes Undergoing Septoplasty (EG)

This arm included male athletes diagnosed with nasal obstruction who underwent surgical correction via septoplasty. Participants were evaluated before and approximately 2-3 months after surgery. Assessments included acoustic rhinometry to measure nasal cavity cross-sectional areas and volumes, the Epworth Sleepiness Scale (ESS), and the Nasal Obstruction Symptom Evaluation (NOSE) scale. Aerobic performance parameters such as running economy, oxygen consumption, and ventilation volume were measured using an incremental treadmill test and respiratory gas analysis.

Group Type: EXPERIMENTAL

Surgical correction of nasal obstruction

Intervention Type: PROCEDURE

Surgical intervention to correct anatomical nasal obstruction, specifically septal deviation, performed under general anesthesia. The procedure involved the repositioning and reshaping of the deviated nasal septum to improve nasal airflow. The surgery was conducted by an otolaryngologist with experience in nasal airway procedures. No additional medications or postoperative interventions beyond standard care (e.g., saline irrigation, analgesics) were administered. Postoperative assessments occurred 2-3 months after surgery, including evaluations of nasal patency, sleep quality, and aerobic performance using treadmill-based gas exchange measurements.

Control Group

Male athletes without nasal obstruction, matched by age and training level with the experimental group. They did not receive any intervention but underwent the same aerobic performance testing protocol at the same time points for comparison.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Surgical correction of nasal obstruction

Surgical intervention to correct anatomical nasal obstruction, specifically septal deviation, performed under general anesthesia. The procedure involved the repositioning and reshaping of the deviated nasal septum to improve nasal airflow. The surgery was conducted by an otolaryngologist with experience in nasal airway procedures. No additional medications or postoperative interventions beyond standard care (e.g., saline irrigation, analgesics) were administered. Postoperative assessments occurred 2-3 months after surgery, including evaluations of nasal patency, sleep quality, and aerobic performance using treadmill-based gas exchange measurements.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

For Experimental Group (EG):

• Diagnosed with nasal obstruction due to septal deviation and/or inferior turbinate hypertrophy
• Experiencing nasal breathing difficulties and sleep disturbance
• Deemed eligible for septoplasty and/or inferior turbinoplasty following physical and endoscopic examination
• Voluntarily agreed to participate in the study
• For Control Group (CG):
• No reported nasal obstruction or breathing complications
• Matched with EG participants by age, sport discipline, training level, and VO₂max (with a maximum variation of ±5%)
• Willing to follow a similar training program to their matched EG counterparts between pre- and post-testing periods

Exclusion Criteria

• History of nasal surgery
• Presence of cardiopulmonary diseases
• Musculoskeletal disorders affecting physical performance or exercise testing
• Inability or unwillingness to follow the pre- and post-test training schedule
• Any surgical complication that would interfere with post-operative participation in physical testing (note: none occurred in this study)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Akdeniz University, Scientific Research Projects Coordination Unit

UNKNOWN

Sponsor Role: collaborator

Tuba Melekoğlu

OTHER

Sponsor Role: lead

Responsible Party

Tuba Melekoğlu

Assoc. Prof.

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Tuba Melekoğlu, Phd

Role: PRINCIPAL_INVESTIGATOR

Akdeniz University Faculty of Sport Sciences

Other Identifiers

TYL-2016-1350

Identifier Type: -

Identifier Source: org_study_id