Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
50 participants
INTERVENTIONAL
2024-12-15
2026-06-30
Brief Summary
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* What is the adaptive response to exercise training on the whole-body and skeletal muscle energy metabolism, insulin sensitivity, metabolic flexibility, muscle functional parameters and cardiopulmonary fitness?
* Would the intensity-related changes of the exercise-induced substrate preference (lipids vs carbohydrates) be a good predictive marker of metabolic flexibility i.e. the capacity to reduce the whole-body metabolic burden in patients with obesity?
* Is the signal driving the adaptive response to regular exercise contained in serum derived Extracellular vesicles?
Researchers will examine effects of exercise training intervention on whole body energy metabolism, by integrating clinical, biochemical and molecular data.
Participants will:
* Undergo 3 months exercise - intervention program.
* Be submitted to examination of their obesity, energy metabolism and cardiopulmonary fitness related phenotypes using bioelectric impedance, indirect calorimetry, cycle spiroergometry.
* Blood samples will be taken both, at the baseline PRE- and POST- intervention.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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lifestyle intervention
supervised lifestyle modification
Supervised lifestyle intervention will consist of regular exercise (3x a week), nutritional counselling (weekly), cognitive bahavioural therapy (monthly).
Control
No interventions assigned to this group
Interventions
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supervised lifestyle modification
Supervised lifestyle intervention will consist of regular exercise (3x a week), nutritional counselling (weekly), cognitive bahavioural therapy (monthly).
Eligibility Criteria
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Exclusion Criteria
20 Years
50 Years
ALL
No
Sponsors
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Medical University Vienna
UNKNOWN
Slovak Academy of Sciences
OTHER_GOV
Responsible Party
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Jozef Ukropec
PhD, DSc
Principal Investigators
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Barbara Ukropcová, Prof. MD PhD
Role: STUDY_CHAIR
Biomedical Research Center Slovak Acad Sci
Jozef Ukropec, PhD, DSc
Role: PRINCIPAL_INVESTIGATOR
Biomedical Research Center Slovak Acad Sci
Locations
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Center for Obesity Management EASO, Biomedical Research Center SAS
Bratislava, Bratislava Region, Slovakia
Countries
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Other Identifiers
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09I03-03-V04-00555
Identifier Type: -
Identifier Source: org_study_id
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