Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-30

Study Completion Date

2021-10-31

Brief Summary

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Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.

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Detailed Description

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Conditions

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Obesity Insulin Resistance Type2 Diabetes Exercise Training

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Exercise Training for six months

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Exercise intervention

Six months of exercise training

Group Type EXPERIMENTAL

Exercise training

Intervention Type BEHAVIORAL

Subjects are required to exercise four times a week during six months. Exercise training consists of endurance training, resistance training and high-intensity interval training adjusted to subject's fitness level.

Interventions

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Exercise training

Subjects are required to exercise four times a week during six months. Exercise training consists of endurance training, resistance training and high-intensity interval training adjusted to subject's fitness level.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* monozygotic twins
* body mass index (BMI) difference ≥ 2 kg/m2 and/or type 2 diabetes
* At least one co-twin is overweight (BMI \> 25 kg/m2)

Exclusion Criteria

* BMI \> 60 kg/m2
* body weight \> 170 kg
* waist circumference \> 150 cm
* mental disorder or poor compliance
* eating disorder or excessive use of alcohol
* active ulcus disease
* diabetes requiring insulin treatment or fasting glucose \> 10 mmol/l
* pregnancy
* past dose of radiation
* claustrophobia
* presence of ferromagnetic objects that would make MRI contraindicated

Minimum Eligible Age

30 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes