Photodynamic Therapy for Glioblastoma Multiforme Based on Metaverse and Yellow Fluorescence

NCT ID: NCT06939400

Last Updated: 2025-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-01

Study Completion Date

2027-12-31

Brief Summary

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GBM patients receiving PDT treatment (50 cases,surgery combined with photodynamic therapy) and traditional treatment (50 cases,traditional surgery) in our hospital and partner hospitals were collected. The prognosis was analyzed by comparing with the control group from multiple perspectives such as image evaluation, imaging effect, Karnofsky score, median survival time and survival rate.

Detailed Description

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Conditions

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Glioblastoma Multiforme (GBM)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

GBM patients recevied traditional treatment options (including surgery combined with radiotherapy and chemotherapy)

GBM patients recevied traditional treatment options

Intervention Type PROCEDURE

GBM patients recevied traditional treatment options (including surgery combined with radiotherapy and chemotherapy)

Treatment

GBM patients recevied surgical combination photodynamic therapy

Photodynamic therapy (PDT)

Intervention Type PROCEDURE

GBM patients recevied surgical combination photodynamic therapy

Interventions

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Photodynamic therapy (PDT)

GBM patients recevied surgical combination photodynamic therapy

Intervention Type PROCEDURE

GBM patients recevied traditional treatment options

GBM patients recevied traditional treatment options (including surgery combined with radiotherapy and chemotherapy)

Intervention Type PROCEDURE

Other Intervention Names

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Surgical combination photodynamic therapy

Eligibility Criteria

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Inclusion Criteria

Pathologically confirmed primary focal GBM; Recurrent GBM(single or satellite lesions); Multiple (multiple germinal centers)GBM.

Exclusion Criteria

* Photosensitizer allergy.

* Severe coagulation disorder.

* Patients with severe cardiovascular and cerebrovascular diseases, especially patients in the acute stage.

* Multiple organ failure, end-stage patients. ⑤ Pregnant women: Photofrin is considered a class C pregnancy risk (toxic, non-teratogenic) drug with non-dialysis properties.

Non-gbm diagnosis: Patients with other types of brain tumors or diseases. 7 Do not agree to informed consent: patients who are unwilling to sign informed consent or do not agree to participate in the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Second Affiliated Hospital of Harbin Medical University

OTHER

Sponsor Role collaborator

Zhejiang Provincial People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hushaoshan

Head of neurosurgery department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

Site Status

Countries

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China

Central Contacts

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Shaoshan Hu, Doctor

Role: CONTACT

0571-85893451 ext. 0571-85893451

Yi Yuan, Doctor

Role: CONTACT

0571-85893451

Facility Contacts

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Yi Yuan, Doctor

Role: primary

0571-85893451

Other Identifiers

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KY2024208

Identifier Type: -

Identifier Source: org_study_id

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