Imaging and Treatment Planning for Cardiac Radioablation

NCT ID: NCT06938074

Last Updated: 2025-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-01

Study Completion Date

2026-09-01

Brief Summary

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Cardiac radioablation is a new treatment for ventricular tachycardia (VT), which uses beams of radiation to treat heart scar that causes VT. To identify the scar areas, magnetic resonance imaging (MRI) and computed tomography (CT) imaging are often used. These are both types of medical imaging that allow clinicians to examine scar area without having to do invasive surgery.

Researchers have developed new heart imaging protocols using both MRI and CT. Their MRI protocol method can now spot both dense and scattered scar tissue. The CT protocol combines multiple different types of scans into a single appointment and uses a special scanner that captures the motion of the heart. For this study, patients will undergo CT and MRI imaging according to these new imaging protocols.

With this study, researchers aim to show that these new imaging protocols can be undergone by patients with ventricular tachycardia and can be used to identify scar. Researchers will also use these scans to make radiation treatment plans to identify which types of treatment can be delivered safely to patients.

Detailed Description

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Conditions

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Ventricular Tachycardia, Monomorphic Ventricular Tachycardia (V-Tach) Ischemia, Myocardial

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CT and MRI

All participants will undergo both CT imaging and MRI imaging to identify areas of ischemic scar. Treatment plans will be created based on CT scans, using various treatment delivery and motion management techniques.

Group Type EXPERIMENTAL

CT and MRI

Intervention Type DIAGNOSTIC_TEST

All participants will undergo both CT imaging and MRI imaging to identify areas of ischemic scar. Treatment plans will be created based on CT scans, for all participants using various treatment delivery and motion management techniques.

Interventions

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CT and MRI

All participants will undergo both CT imaging and MRI imaging to identify areas of ischemic scar. Treatment plans will be created based on CT scans, for all participants using various treatment delivery and motion management techniques.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Ischemic cardiomyopathy with monomorphic VT
* Referred by cardiologists

Exclusion Criteria

* • Polymorphic ventricular tachycardia
* Ventricular fibrillation
* Pregnant or breastfeeding or planning to become pregnant or breastfeed during the study
* Estimated glomerular filtration rate ≤ 30 mL/min/1.73m2
* Previous allergic reaction to CT contrast agent Note that participants with contraindications for MRI can still be enrolled in this study but will not undergo MRI parts of this protocol.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stewart Gaede

OTHER

Sponsor Role lead

Responsible Party

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Stewart Gaede

Chief Medical Physicist

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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London Health Sciences Centre Research Inc

London, Ontario, Canada

Site Status

Countries

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Canada

Central Contacts

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Stewart Gaede, PhD

Role: CONTACT

519-685-8600 ext. 53144

Facility Contacts

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Stewart Gaede, PhD

Role: primary

5196858600 ext. 53144

Other Identifiers

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126882

Identifier Type: -

Identifier Source: org_study_id

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