Effectiveness of One-Minute Versus Two-Minute Cryoanalgesia in Nuss Surgery

NCT ID: NCT06935799

Last Updated: 2025-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-25

Study Completion Date

2026-03-31

Brief Summary

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Intercostal nerve cryoanalgesia has become a popular method for managing postoperative pain after Nuss procedure, showing greater effectiveness compared to epidural anesthesia and patient-controlled analgesia. However, the optimal duration of cryoanalgesia remains unknown. Most protocols use a two-minute cryoablation, although histological studies show similar changes with both one-minute and two-minute applications.

This is a pilot, single-center, randomized, double-blind study comparing the effectiveness of one-minute versus two-minute cryoanalgesia in treating pain in patients undergoing correction of pectus excavatum using the Nuss procedure. The aim of the project is to evaluate the validity of the research procedure and determine the sample size for the main study. Preliminary data on postoperative pain intensity, opioid consumption, duration of surgery, length of hospital stay, and complications will be analyzed.

Detailed Description

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Conditions

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Pectus Excavatum Funnel Chest

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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One minute cryoanalgesia

Group Type EXPERIMENTAL

One minute intercostal nerves cryoanalgesia

Intervention Type PROCEDURE

One-minute cryoanalgesia will be applied bilaterally to each of the intercostal nerves from Th3 to Th7

Two minutes cryoanalgesia

Group Type ACTIVE_COMPARATOR

Two minutes intercostal nerves cryoanalgesia

Intervention Type PROCEDURE

Two-minutes cryoanalgesia will be applied bilaterally to each of the intercostal nerves from Th3 to Th7

Interventions

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One minute intercostal nerves cryoanalgesia

One-minute cryoanalgesia will be applied bilaterally to each of the intercostal nerves from Th3 to Th7

Intervention Type PROCEDURE

Two minutes intercostal nerves cryoanalgesia

Two-minutes cryoanalgesia will be applied bilaterally to each of the intercostal nerves from Th3 to Th7

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Pectus excavatum repair with MIRPE
* Written consent for corrective surgery with intraoperative cryoanalgesia
* Written consent to participate in the study
* Age \>12 and \< 18 years

Exclusion Criteria

* History of previous thoracic surgeries
* Reoperation for chest deformity
* Contraindication for cryoanalgesia
* Presence of other conditions that may affect the course of the procedures and the assessment of their effectiveness and safety
Minimum Eligible Age

12 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Children's Memorial Health Institute, Poland

OTHER

Sponsor Role lead

Responsible Party

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Mateusz Ciopiński

Principal Investigator, Department of Pediatric Surgery and Organ Transplantation, CMHI

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Children's Memorial Health Institute

Warsaw, Wybierz Województwo, Poland

Site Status RECRUITING

Countries

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Poland

Facility Contacts

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Mateusz Ciopiński, MD, PhD

Role: primary

0048228151360

Other Identifiers

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37/KBE/2024

Identifier Type: -

Identifier Source: org_study_id

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