Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2025-01-06
2026-11-30
Brief Summary
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Detailed Description
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Shape cues the task to perform. Squares indicate the standard baseline task, and each block begins and ends with baseline trials. Different shapes indicate sub-tasks. In Switching blocks, shape-switches (e.g. from square to circle or circle to square) cue the sequence start task. Shape-repeats cue the sequence 1-back task. In Planning blocks, triangle shapes indicate that the stimulus can be ignored (automatic "no" response). All the while, the last square-shaped stimulus must be retained as a reference for the next square-shaped stimulus. Finally, in Dual blocks, diamond shapes indicate switching (sequence start) and also planning. The reversion back to square shapes requires sequence matching to the distal, previous square.
The design is factorial with stimulus-domain x contextual control x temporal control orthogonally manipulated. Full details of the CCT have been previously described in published work.
The focus in this study will be comparison of MFG-TMS, IPL-TMS, and S1-TMS in an interleaved fMRI-TMS-fMRI design. The logic is to test the apical status of the MFG/IPL through the extent to which TMS impacts other PFC/PPC areas and behavior.
Each experiment will begin with 1 session of the CCT with fMRI to localize TMS targets. Each participant will then perform 3 counter-balanced sessions wherein a different site will be targeted by TMS followed immediately by fMRI on the CCT.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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MFG-TMS
Transcranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of resting motor threshold.
transcranial magnetic stimulation
Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.
IPL-TMS
Transcranial magnetic stimulation to the inferior parietal lobule. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of resting motor threshold.
transcranial magnetic stimulation
Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.
S1-TMS
Transcranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of resting motor threshold.
transcranial magnetic stimulation
Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.
Interventions
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transcranial magnetic stimulation
Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.
Eligibility Criteria
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Inclusion Criteria
* Right-handed
* Native English speaker or fluent by the age of 6
Exclusion Criteria
* History of neurological disorders
* Receiving medications for psychiatric or neurological disorders
* Familial history of epilepsy
* Taking any drugs or medications that are pro-epileptic
* Tinnitus
* Women who are pregnant
18 Years
30 Years
ALL
Yes
Sponsors
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National Institute of Mental Health (NIMH)
NIH
Florida State University
OTHER
Responsible Party
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Derek Nee
Associate Professor
Principal Investigators
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Derek Nee, PhD
Role: PRINCIPAL_INVESTIGATOR
Florida State University
Locations
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Florida State University Psychology Department Building
Tallahassee, Florida, United States
FSU MRI Facility
Tallahassee, Florida, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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0000033961
Identifier Type: -
Identifier Source: org_study_id
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