A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

NCT ID: NCT06909500

Last Updated: 2025-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

1372 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-03-01

Study Completion Date

2027-05-01

Brief Summary

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This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes). E-cigarettes pose numerous risks, particularly to youth and young adults. Addressing the high prevalence of e-cigarette use by young adults requires effective and accessible treatments to support current users to quit. Research shows this group prefers and benefits from newer methods of treatment delivery such as digital interventions. ACT on Vaping is a digital therapeutic intended to deliver behavioral therapy to young adults who vape to motivate and support abstinence from all nicotine and tobacco products. The app contains sessions that promote awareness of cues that trigger tobacco use and teach skills for responding to these triggers in a way that is tailored for the participant's readiness to quit. Receiving access to the ACT on Vaping app may be effective in helping young adults quit vaping.

Detailed Description

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OUTLINE: Participants are randomized to 1 of 2 arms.

ARM I: Participants use the ACT on Vaping app (Version A) and receive a text messaging program to motivate and support quitting. Participants also receive incentivized text message check-ins at 2 weeks, 2 months, and 4 months to assess their vaping status.

ARM II: Participants use the ACT on Vaping app (Version B) and receive incentivized text message check-ins at 2 weeks, 2 months, and 4 months to assess their vaping status.

After completion of study intervention, participants are followed up at 3 and 6 months.

Conditions

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Nicotine Dependence Tobacco-Related Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors
The control app will also be called ACT on Vaping in participant-facing materials, for blinding purposes; Any outcome evaluator who has direct contact with participants will remain blinded to treatment group assignment.

Study Groups

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Arm II (ACT on Vaping app (Version B) + incentivized texts)

Participants receive access to the ACT on Vaping app including health education content. Participants receive incentivized text message check-ins at 2 weeks, 2 months, and 4 months to assess changes in vaping on study.

Group Type SHAM_COMPARATOR

Smartphone app

Intervention Type BEHAVIORAL

Receive access to the ACT on Vaping app

Text Message

Intervention Type OTHER

Receive incentivized text messages to access vaping status

Survey Administration

Intervention Type OTHER

Ancillary studies

Arm I (ACT on Vaping app (Version A) + incentivized texts + intervention texts)

Participants receive access to the ACT on Vaping app utilizing Acceptance and Commitment Therapy. Participants also receive text message intervention content, as well as incentivized text message check-ins at 2 weeks, 2 months, and 4 months to assess changes in vaping on study.

Group Type EXPERIMENTAL

Smartphone app

Intervention Type BEHAVIORAL

Receive access to the ACT on Vaping app

Text Message

Intervention Type OTHER

Receive incentivized text messages to access vaping status

Text Message

Intervention Type OTHER

Receive intervention text messages

Survey Administration

Intervention Type OTHER

Ancillary studies

Interventions

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Smartphone app

Receive access to the ACT on Vaping app

Intervention Type BEHAVIORAL

Smartphone app

Receive access to the ACT on Vaping app

Intervention Type BEHAVIORAL

Text Message

Receive incentivized text messages to access vaping status

Intervention Type OTHER

Text Message

Receive intervention text messages

Intervention Type OTHER

Survey Administration

Ancillary studies

Intervention Type OTHER

Other Intervention Names

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ACT on Vaping (Version A) ACT on Vaping (Version B) SMS Text SMS Text

Eligibility Criteria

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Inclusion Criteria

* Age 18-30
* Age of majority (to provide informed consent) in current state/territory of residence
* Current weekly user of e-cigarette product(s) for the last 30 days
* Has a smartphone; either an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)
* Experience downloading and using one or more apps on their smartphone
* Have a mobile data plan and/or access to WiFi to support the use of the ACT on Vaping app
* Has access to text messaging
* Has an email address
* United States (US) resident, with a US mailing address
* Willing to complete all study procedures
* Comfortable reading and writing in English

Exclusion Criteria

* Currently using other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (note: use of these treatment is allowable during trial participation)
* Member of the same household as another research participant
* Currently in prison
* Google voice number as sole phone number, due to its association with fraudulent study entry attempts
* Is ineligible per fraud prevention protocol
* Employees/family of investigator or study center
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

Fred Hutchinson Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jaimee Heffner, PhD

Role: PRINCIPAL_INVESTIGATOR

Fred Hutch/University of Washington Cancer Consortium

Locations

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Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, United States

Site Status

Countries

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United States

Central Contacts

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Jaimee Heffner, PhD

Role: CONTACT

206-667-7314

Facility Contacts

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Jaimee Heffner, PhD

Role: primary

206-667-7314

Other Identifiers

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NCI-2025-01611

Identifier Type: REGISTRY

Identifier Source: secondary_id

UH3DA057032

Identifier Type: NIH

Identifier Source: secondary_id

View Link

RG1125194

Identifier Type: -

Identifier Source: org_study_id

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