Post-immunotherapy Nephrectomy for Metastatic Kidney Cancer After Complete or Major Response to Systemic Therapy

NCT ID: NCT06882486

Last Updated: 2025-03-18

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-09-30
• Study Completion Date: 2030-09-30

Brief Summary

In the current era of immune checkpoint inhibitors (ICI), the role and timing of nephrectomy remains unknown, particularly in cases of residual kidney disease after a major response at metastatic sites. In these cases, the rationale for a delayed nephrectomy is that it might achieve a long-term response. This strategy could allow some patients to discontinue treatment and maintain tumor response. Furthermore, this approach might provide a potentially curative option for patients with metastases that are managed with and responding to ICI.

Regarding the results of our first retrospective cohort data (showing that two thirds of patients are free from recurrence without systemic treatment after nephrectomy), we designed a non-comparative randomized phase II trial assessing progression-free survival of patients with complete response or major partial response after ICI-based treatment, operated on delayed nephrectomy with discontinuation of systemic therapy (experimental arm) and in patients managed with continuation of systemic therapy without nephrectomy (control arm).

In a de-escalation approach, this strategy may have sense to allow patients with an excellent response to immunotherapy to stop systemic treatment with a curative objective and a substantial impact from a medico-economic point of view.

Detailed Description

Patients with metastatic kidney cancer will be treated according to current first-line treatment guidelines.

Patients may be included in the study (by signing a consent form) and randomized if a complete response (CR) or metastatic partial response (mPR) (>75%) is achieved with immunotherapy-based systemic therapy.

In the centers participating in the ancillary study, patients in the experimental arm (arm A) will undergo renal MRI and PSMA PET (positron emission tomography) scan prior to nephrectomy.

Arm A patients will undergo nephrectomy (partial or enlarged, depending on technical possibilities and surgeon's discretion), after which systemic treatment will be discontinued.

Patients in arm B will not undergo surgery, and will continue their systemic treatment unchanged (interrupted in the event of toxicity, in accordance with current recommendations).

In both arms, follow-up will consist of a biological and CT scan evaluation every 3 months for 2 years.

The primary objective is to evaluate the efficacy of the experimental strategy in terms of progression-free survival, progression being defined according to the usual RECIST criteria.

Conditions

Kidney Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

nephrectomy

delayed nephrectomy and discontinuation of systemic treatment

Group Type: EXPERIMENTAL

nephrectomy

Intervention Type: PROCEDURE

Nephrectomy scheduled within 3 months of inclusion. Patients may continue their systemic treatment at the usual rate until D-5 prior to surgery. Treatment will not be resumed after surgery. Surgery may consist of partial or enlarged nephrectomy, with or without associated lymph node dissection, depending on technical possibilities and at the surgeon's discretion.

no nephrectomy

no nephrectomy and continuation of systemic treatment

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

nephrectomy

Nephrectomy scheduled within 3 months of inclusion. Patients may continue their systemic treatment at the usual rate until D-5 prior to surgery. Treatment will not be resumed after surgery. Surgery may consist of partial or enlarged nephrectomy, with or without associated lymph node dissection, depending on technical possibilities and at the surgeon's discretion.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Patient aged ≥ 18 years

2. Diagnosed with synchronous metastatic kidney cancer

3. With primary tumor still in place (no primary cytoreductive nephrectomy)

4. Having received systemic ICI immunotherapy-based combination therapy

5. In CR or mPR (defined as >75% response in metastatic lesions from baseline) according to the Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1), excluding the primary renal lesion.

6. Signed consent to participate

7. Affiliated to the national social security scheme or beneficiaries of such a scheme

Exclusion Criteria

1. Women who are or may become pregnant (without effective contraception) or who are breast-feeding.

2. Person in an emergency situation or unable to give consent.

3. An adult under legal protection (guardianship, curators or safeguard of justice),

4. Inability to undergo medical follow-up for geographical, social or psychological reasons.

5. Patients who have undergone prior cytoreductive nephrectomy

6. Patients considering nephrectomy for symptomatic disease, but without major response (CR or mPR) in metastatic disease

7. Patients with non-metastatic disease at diagnosis who have received ICI in a neo-adjuvant setting

8. Patients with contraindications to surgery or ineligible for nephrectomy

9. Patients not wishing to undergo nephrectomy

10. Patients with end-stage renal disease

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Institut Paoli-Calmettes

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

NAMECAR-IPC 2024-054

Identifier Type: -

Identifier Source: org_study_id