Antiplatelet Strategy for CCS Patients Undergoing CABG

NCT ID: NCT06881901

Last Updated: 2025-03-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 29898 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-01-01
• Study Completion Date: 2022-12-31

Brief Summary

To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG. A retrospective, population-based cohort study was conducted using data from the Korean National Health Insurance Service (K-NHIS) database.

Detailed Description

The use of antiplatelet agents is crucial in preventing atherothrombotic complications and maintaining graft patency after coronary artery bypass grafting (CABG). While dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is recommended for one year in patients undergoing CABG for acute coronary syndrome (ACS), the optimal antiplatelet strategy for chronic coronary syndrome (CCS) remains unclear. In fact, current guidelines show discrepancies, with the American Heart Association/American College of Cardiology (AHA/ACC) recommending DAPT for one year to reduce the risk of saphenous vein graft (SVG) occlusion (Class IIb), while the European Society of Cardiology (ESC) recommends switching to aspirin monotherapy to reduce bleeding risk and considers DAPT only for high-risk patients (Class IIb). However, aspirin monotherapy may also not be the optimal alternative due to its limited efficacy in preventing thrombotic events and its inability to significantly reduce major bleeding compared to DAPT. Recently, clopidogrel monotherapy has emerged as a promising alternative, potentially offering both ischemic protection and a lower bleeding risk compared to DAPT even compared to aspirin monotherapy. An observational study comparing clopidogrel monotherapy with clopidogrel plus aspirin after CABG found that clopidogrel monotherapy demonstrated comparable to the combination therapy group. While this suggests that clopidogrel monotherapy could be a viable alternative, previous study was limited by its short follow-up duration and lack of bleeding outcome assessment. Thus, the investigators performed target trial emulation to evaluate long-term ischemic and bleeding outcomes associated with DAPT, aspirin monotherapy, and clopidogrel monotherapy in CCS patients following CABG.

Conditions

Chronic Coronary Syndrome; Coronary Artery Bypass Graft CABG

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Dual antiplatelet therapy

Patients who were prescribed dual antiplatelet therapy (aspirin + clopidogrel) at the date of discharge from te index hospitalization for CABG

No interventions assigned to this group

Aspirin monotherapy

Patients who were prescribed single antiplatelet therapy (aspirin) at the date of discharge from te index hospitalization for CABG

No interventions assigned to this group

Clopidogrel monotherapy

Patients who were prescribed single antiplatelet therapy (clopidogrel) at the date of discharge from te index hospitalization for CABG

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients with underwent Coronary artery bypass surgery (CABG) between January 2010 and December 2020

Exclusion Criteria

• In-hospital death
• Not prescribed SAPT or DAPT
• Received CABG due to myocardial infarction or had myocardial infarction
• Received CABG due to unstable angina or had unstable angina
• History of PCI
• Pre-existing Intracranial hemorrhage or gastrointestinal bleeding
• Oral anticoagulant prescription at discharge

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Samsung Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Ki Hong Choi

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

Antiplatelet After CABG

Identifier Type: -

Identifier Source: org_study_id