Genetic Variants of Annexin A2 and Cryptogenic Stroke

NCT ID: NCT06880107

Last Updated: 2026-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-08

Study Completion Date

2027-04-30

Brief Summary

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Stroke is the third most common cause of death in developed countries. Various mechanisms of ischemic stroke exist. However, in young population, in a third of cases, the cause of a stroke cannot be determined despite an extensive evaluation. Many studies have highlighted the link between stroke and fibrinolysis. Genetic variants of tPA and PAI-1 genes have been suggested to be the risk factors for stroke.

ANXA2 plays a pivotal role in plasmin generation and fibrinolysis. Several studies showed the role of ANXA2 and S100A10 subunits in regulation of fibrinolysis in vivo. Recently, the efficacy of recombinant ANXA2 for fibrinolytic therapy in a rat embolic stroke has been demonstrated. Some single nucleotide polymorphisms in ANXA2 gene could be associated with increased risk of stroke in sickle cell disease.

Therefore, these data invite us to test hypothesis that genetic variants of ANXA2 gene could be associated with ischemic stroke.

Detailed Description

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Conditions

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Stroke Annexin A2 Genetic Variants of Host Fibrinolysis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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cryptogenic stroke

cryptogenic stroke

Group Type EXPERIMENTAL

blood withdrawal

Intervention Type BIOLOGICAL

blood withdrawal

ischemic stroke

ischemic stroke

Group Type EXPERIMENTAL

blood withdrawal

Intervention Type BIOLOGICAL

blood withdrawal

control subjects

control subjects

Group Type ACTIVE_COMPARATOR

blood withdrawal

Intervention Type BIOLOGICAL

blood withdrawal

Interventions

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blood withdrawal

blood withdrawal

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Completed ischemic stroke defined as a rapidly developing focal neurologic deficit with no apparent cause other than a vascular origin that persisted beyond 24 hours in surviving patients
* Age from 18 years old

Exclusion Criteria

* Transient ischemic attack
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHRU Amiens

Amiens, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Valéry SALLE, MD

Role: CONTACT

33+3 22 66 82 30

Facility Contacts

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Valéry Salle, MD

Role: primary

33+3 22 66 82 30

Other Identifiers

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PI2023_843_0150

Identifier Type: -

Identifier Source: org_study_id

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