Usefulness of Post-Operative Radiotherapy in High-grade Cutaneous Squamous Cell Carcinoma: an Observational Study
NCT ID: NCT06879964
Last Updated: 2025-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
120 participants
OBSERVATIONAL
2023-11-17
2028-12-31
Brief Summary
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Most recent guide lines from NCCN, Sidemast and British associations of dermatologists suggest clinicians to offer or consider PORT in selected patients but class nor level of evidence of those guide lines are provided.
This project evaluates impact of post-operative radiotherapy on recurrence rate and overall survival by comparing two cohort of patients, the former who accepted PORT and the latter who, nonetheless its necessity, decided to not undergo it.
The hypothesis which this project will answer concerns the effectiveness of post-operative radiotherapy in preventing local and regional recurrences. We expect a significant decrease of recurrence rate in patients who undergo this therapeutic option as compared to those with clinical indication but do not undergo PORT.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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patients with high-grade cutaneous squamous cell carcinoma
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* patients eligible for post-operative radiotherapy
* minimum follow-up of 24 months
Exclusion Criteria
* impossibility of a proper follow-up
* occurrence of intermediate events (i.e., pregnancy)
18 Years
ALL
No
Sponsors
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Fondazione IRCCS Policlinico San Matteo di Pavia
OTHER
Responsible Party
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Chiara Giorgini
MD
Locations
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Fondazione IRCCS Policlinico San Matteo, SC Dermatologia
Pavia, Pavia, Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PORTSCC
Identifier Type: -
Identifier Source: org_study_id
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