Tissue Inhibitor of Metalloproteinases 2 Level in Patients Undergoing Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-22

Study Completion Date

2025-01-25

Brief Summary

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Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Tissue Inhibitor of Metalloproteinases 2 (TIMP2) is associated with ischemia-reperfusion injury. In this study, relationship between TIMP2 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of TIMP2 for early prediction of CSA-AKI was further evaluated.

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Detailed Description

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Conditions

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Acute Kidney Injury Extracorporeal Circulation; Complications Surgery

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

TIMP2 level

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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TIMP2 Tertile 1

Other: TIMP2 level

Group Type EXPERIMENTAL

TIMP2 level

Intervention Type DRUG

different TIMP2 level after on-pump cardiac surgery

TIMP2 Tertile 2

Other: TIMP2 level

Group Type EXPERIMENTAL

TIMP2 level

Intervention Type DRUG

different TIMP2 level after on-pump cardiac surgery

TIMP2 Tertile 3

Other: TIMP2 level

Group Type EXPERIMENTAL

TIMP2 level

Intervention Type DRUG

different TIMP2 level after on-pump cardiac surgery

Interventions

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TIMP2 level

different TIMP2 level after on-pump cardiac surgery

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients (≥18 years old) underwent on-pump cardiac surgery
* admitted to ICU immediately after surgery

Exclusion Criteria

* Patients younger than 18 years
* with prior AKI
* end-stage kidney disease
* need for chronic hemodialysis
* pregnant patients
* unable to give written consent for participation

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No