Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19

NCT ID: NCT06864156

Last Updated: 2025-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-02-18

Study Completion Date

2025-07-31

Brief Summary

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At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue. This project seeks to analyze some blood components of people with long COVID, such as microRNAs and vitamin B12, in order to identify the body processes that changed after COVID-19 and thereby design better therapies and diagnostic methods focused on each of them.

The hypothesis is that the expression of miR-21, -146a and -155 will be overexpressed as well as there will be a deficiency of vitamin B12 in serum in subjects suffering from long COVID with neurological symptoms of depression, anxiety and fatigue.

Detailed Description

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Conditions

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Long COVID Long COVID Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Long COVID

With presence of neurological symptoms of depression, anxiety and fatigue associated with COVID-19 three months after the first day with symptoms of acute infection

No interventions assigned to this group

Control

Not presented symptoms associated with COVID-19 twelve weeks after the first day with symptoms of acute infection

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Subjects with confirmed diagnosis of COVID-19 by SARS-CoV-2 infection by PCR or antigen testing.
* With presence of neurological symptoms of depression, anxiety and fatigue associated with COVID-19 after three months from the first day of acute infection symptoms.

Exclusion Criteria

* Subjects who have presented symptoms of acute infection in the last twelve weeks.
* Subjects who present diagnostic premorbid neurological alterations.
* Subjects who do not have at least 2 doses of COVID-19 vaccine, with last application date equal or older than 3 months.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Instituto Nacional de Rehabilitacion

OTHER_GOV

Sponsor Role lead

Responsible Party

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Alfonso B. Alfaro

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Instituto Nacional de Rehabilitación

Mexico City, Mexico City, Mexico

Site Status RECRUITING

Countries

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Mexico

Facility Contacts

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Alfonso Alfaro Rodriguez, Doctorado

Role: primary

55 5999 1000 ext. 19305

Other Identifiers

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03/24 AD 2025

Identifier Type: -

Identifier Source: org_study_id

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