En Bloc Resection of the Liver and Pancreas With a "Non-touch" Technique Followed by Liver Transplantation to Improve the Overall Survival in Patients With Non-resectable Hilar Cholangiocarcinoma Beyond the Mayo Clinic Transplant Criteria

NCT ID: NCT06850753

Last Updated: 2025-08-21

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-01
• Study Completion Date: 2030-12-31

Brief Summary

Surgery for hilar cholangiocarcinoma (phCCA) remains a significant challenge. The minority of patients who are eligible for resection are exposed to high procedure-related morbidity and mortality, and despite apparent R0 resection, cancer recurrence is common. The benefit of R1 resection compared to the best palliative chemotherapy has been questioned. The concept of extended surgery to achieve better radicality is controversial and in many instances, associated with higher procedure-related risk and unclarified oncological benefit. For unresectable patients, liver transplantation, per the Mayo protocol, remains the only alternative for a few patients.

Optimal staging pre- and intraoperatively is problematic since only the local biliary ductal involvement and, to a certain extent, lymph node dissemination can be reasonably correctly assessed. The reliability and validity of the intraoperative frozen section have been questioned. Furthermore, microscopic tumor cell affection leading to recurrent disease has been found in 16% of presumed N0 lymph nodes when analyzed by immunohistochemistry, and patients with nodal micrometastasis showed the same dismal survival as those with positive nodes on regular pathology (pN1).

Taken together, there is a lack of good surgical options for patients with marginally or unresectable phCCA that do not satisfy current criteria for liver transplantation.

The practical problem in the current surgical techniques for hilar cholangiocarcinoma, particularly in locally advanced disease, is that the hepatoduodenal ligament, in most instances, represents an incompletely staged operative field, making the probability of obtaining true free margins uncertain.

An alternative procedure must, therefore, consider the anatomical and multidimensional pattern of dissemination and the limitations in the accurate staging of phCCA, and this suggests that a wider surgical margin is needed to obtain radical resection in locally advanced phCCA.

The aim of the current study is tho these the following hypothesis:

Locally advanced hilar cholangiocarcinoma without M1 lymph node metastatic disease can be radically resected by extending the surgical margin to include the complete hepatobiliary axis and the main anatomical trajectories of local and regional dissemination through an "en-bloc" surgical approach.

M1 metastatic disease is defined as positive nodes in the following locations at staging:

• Station 9: lymph nodes around the celiac axis.
• Station 14: lymph nodes along the superior mesenteric artery or vein.
• Station 15: lymph nodes along the middle colic vein.
• Station 16: para-aortic lymph nodes.

Patients will be treated by chemotherapy and radiation therapy with an observation period of at least 6 months showing response or stable disease before final inclusion.

The operative procedure consists of a superior right abdominal exenteration, including the liver, pancreas, spleen, and vena cava + liver transplantation. If islets are available from the same donor, this will be administered postoperatively according to the institutional protocol.

Main enpoint is overall survival at 1, 3 and 5 years

Conditions

Cholangiocarcinoma Non-resectable; Cholangiocarcinoma Recurrent; Liver Transplantation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Liver transplantation for locally advaced hilar cholangiocarcinoma

Patients with hilar cholangiocarcinoma outside current transplant criteria will be treated with neoadjuvant chemotherapy + radiation and, after an observation period of a minimum of 6 months, undergo an exenteration of the liver and pancreas "en-bloc" + liver transplantation.

Group Type: EXPERIMENTAL

Liver transplantation after en bloc resection of the liver and pancreas

Intervention Type: PROCEDURE

Exenteration of the upper right part of the abdomen, including the liver and pancreas en bloc in locally advanced hilar cholangiocarcinoma, followed by liver transplantation

Interventions

Liver transplantation after en bloc resection of the liver and pancreas

Exenteration of the upper right part of the abdomen, including the liver and pancreas en bloc in locally advanced hilar cholangiocarcinoma, followed by liver transplantation

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Histologically verified or strong suspicion of cholangiocarcinoma based on radiology and endoscopy and elevated Ca 19-9 > 100U/L
• Perihilar cholangiocarcinoma that is deemed unresectable based on tumor location or severity of the underlying liver disease. Perihilar recurrence in PSC patients more than 24 months following the previous resection (N0, R0, no macrovascular involvement) is accepted.
• Patients should not be eligible for liver transplantation according to the Mayo protocol criteria.
• Tumor involvement of the hepatic artery distal to the gastroduodenal artery or the portal vein without tumor thrombus is accepted.
• No evidence of distant metastasis or metastatic lymph node (M1) involvement (para-aortic, coeliac or para-colic)
• Good performance status Eastern Cooperative Oncology Group (ECOG) performance status score 0 or 1
• At least 6 months of observation time during which the patient should be treated by chemotherapy and radiation (hyperfractioned 30-50 Gy) with response or stable disease before listing for LT. Patients with PSC and significant liver dysfunction that restricts the tolerability of chemoradiotherapy may be considered on an individual basis

Exclusion Criteria

• Radiological signs of tumor invasion along intended resection borders
• Direct tumor invasion of the pancreatic head
• Signs of spread to the para-aortic, superior mesenteric, or coeliac lymph nodes
• Perforation of the visceral peritoneum
• Weight loss >10% in the last six months
• Patient BMI > 30 kg/m2
• Other malignancies, except curatively treated basal cell carcinoma or other tumors with disease-free interval > five years without relapse. The final decision on acceptable previous cancer diagnoses is at the principal investigator's discretion.
• Known history of human immunodeficiency virus (HIV) infection
• Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results
• Known hypersensitivity to rapamycin
• Prior metastatic disease
• Women who are pregnant or breastfeeding
• Any reason why, in the opinion of the investigator, the patient should not participate

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Oslo University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Pål-Dag Line

Professor, Senior Consultant Transplant Surgeon

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Pål-Dag Line, MD PhD

Role: STUDY_CHAIR

Oslo University Hospital

Locations

Oslo University Hospital

Oslo, , Norway

Site Status: RECRUITING

Countries

Norway

Central Contacts

Pål-Dag Line, MD PhD

Role: CONTACT

paaldl@uio.no

23070509 ext. +47

Sheraz Yaqub, MD PhD

Role: CONTACT

sheraz.yaqub@medisin.uio.no

90953996 ext. +47

Facility Contacts

Pål-Dag Line, MD PhD

Role: primary

paaldl@uio.no

23070509 ext. +47

Sheraz Yaqub, MD PhD

Role: backup

sheraz.yaqub@medisin.uio.no

90953996 ext. +47

Other Identifiers

REK743190

Identifier Type: -

Identifier Source: org_study_id