SMS 2: Impact of Cancer Therapy on the Somatic Mutational Landscape of Normal Tissues

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-26

Study Completion Date

2029-05-13

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Recently technology has been developed at the Wellcome Sanger Institute to allow clusters of cells with mutations to be detected in normal and diseased tissues. The researchers wish to determine how the number and nature of these mutant cell clusters change in response to treatments given to cancer patients (such as chemotherapy, radiotherapy, immunotherapy, and drugs targeted at specific mutations in tumours). As such the researchers wish to collect research samples of blood, cheek cells (via swabs) and urine from adult cancer patients receiving the above-mentioned treatments as part of their standard care. The researchers also wish to access any leftover tissue following surgery that is undertaken as part of these patient's treatment.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Exploring the Landscape of Somatic Mutations in Human Tissue

NCT06585800

Somatic Mutation

ENROLLING_BY_INVITATION

Next pErsonalized Cancer tX With mulTi-omics and Preclinical Model

NCT02141152

Metastatic Cancer

COMPLETED

Clinical Sequencing Project for Metastatic Cancer Patients for Personalized Cancer Clinic.

NCT02593578

Metastatic Cancer

UNKNOWN

Characterization of Human Cancers by Molecular Profiling of Patient Biospecimens

NCT02749838

Cancer

UNKNOWN

iSITE: Investigation of Somatic Alterations in Tumours of the Eye

NCT06861647

Somatic Mutation Ocular Melanoma

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Disease and tissue aging are thought to be influenced by genetic changes, or mutations, acquired throughout life. These mutations provide clues regarding the genetic damage that occurred through the lifetime of the patient, and include mutations caused by environmental factors such as ultraviolet light from sunlight or tobacco smoke affecting the skin or internal tissues, respectively. Other mutations may occur due to errors in copying the genome as cells divide. Once a cell has acquired a mutation, the cell's daughters may inherit it. Eventually clusters of cells carrying the same mutation may form within tissues. If the mutations alter cell behaviour this may impact how cells behave and influence how a whole tissue functions.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Somatic Mutation Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Non melanoma skin cancer

Skin cancer patients receiving Immune checkpoint immunotherapy.

sample collection

Intervention Type OTHER

Participants may collected their own cheek swabs and will collect their own urine samples.

Clinical professionals at participating sites will collect blood samples.

Discussing study

Intervention Type OTHER

Research Nurse/ Suitably qualified Research Site Staff will discuss the study with potential participants

Seeking consent

Intervention Type OTHER

Potential participants who wish to give consent will do with a Research Nurse/ Suitably qualified Research Site Staff.

Head and Neck Cancer

Head and Neck cancer patients receiving chemoradiotherapy.

sample collection

Intervention Type OTHER

Participants may collected their own cheek swabs and will collect their own urine samples.

Clinical professionals at participating sites will collect blood samples.

Discussing study

Intervention Type OTHER

Research Nurse/ Suitably qualified Research Site Staff will discuss the study with potential participants

Seeking consent

Intervention Type OTHER

Potential participants who wish to give consent will do with a Research Nurse/ Suitably qualified Research Site Staff.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

sample collection

Participants may collected their own cheek swabs and will collect their own urine samples.

Clinical professionals at participating sites will collect blood samples.

Intervention Type OTHER

Discussing study

Research Nurse/ Suitably qualified Research Site Staff will discuss the study with potential participants

Intervention Type OTHER

Seeking consent

Potential participants who wish to give consent will do with a Research Nurse/ Suitably qualified Research Site Staff.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or Female
* Due to commence systemic treatment for histologically confirmed cancer at a - participating site
* Age over 18 years
* Able to give informed consent.
* Able to give urine, blood and cheek swab samples on two occasions.
* Likely to complete 3 months of treatment

* Any participant who is known to have Hep B, Hep C or HIV

Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No