Orthodontic Treatment on Oral Microbiota and Salivary Proteins

NCT ID: NCT06824493

Last Updated: 2025-06-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-01

Study Completion Date

2027-09-01

Brief Summary

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Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.

Detailed Description

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Conditions

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Orthodontics White Spot Lesions [Initial Caries] on Smooth Surface of Tooth Caries, Dental

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ID number

no interventions

Intervention Type OTHER

no intervention as this is an observational studies

None-placebo

Intervention Type OTHER

Observational study with no interventions

No Intervention: Observational Cohort

Intervention Type OTHER

no intervention because of observational studies

Interventions

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no interventions

no intervention as this is an observational studies

Intervention Type OTHER

None-placebo

Observational study with no interventions

Intervention Type OTHER

No Intervention: Observational Cohort

no intervention because of observational studies

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* No carries and White spot
* No missing teeth
* No history of oral treatment
* No malocclusion
* No systemic diseases

Exclusion Criteria

* Antibiotic use in the past three months
* A history of long-term medication use
* A history of dental fillings
* Unable to attend regular follow-ups
Minimum Eligible Age

6 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Xi'an Jiaotong University

OTHER

Sponsor Role lead

Responsible Party

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Shanshan-Dai

attending physician of pediatric dentist and PhD in Orthodontics

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Shan shan Dai

Role: CONTACT

86+15319976663

Other Identifiers

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XJKQLY202503

Identifier Type: -

Identifier Source: org_study_id

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