Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant Recipients

NCT ID: NCT06824454

Last Updated: 2025-02-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-31

Study Completion Date

2026-03-31

Brief Summary

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The primary goal is to determine if Dipyridamole can improve serum phosphate levels and reduce the need for phosphate supplementation.

Detailed Description

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Conditions

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Hypophosphatemia Kidney Transplantation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment Group

Participants receive Dipyridamole in addition to standard post-transplant care.

Group Type EXPERIMENTAL

Dipyridamole 75 MG

Intervention Type DRUG

Dipyridamole administered three times daily when serum phosphorus levels fall below 4 mg/dL. The drug is used off-label for this study to manage hypophosphatemia in kidney transplant recipients.

Control Group

Participants in this group will receive standard post-transplant care without Dipyridamole.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Dipyridamole 75 MG

Dipyridamole administered three times daily when serum phosphorus levels fall below 4 mg/dL. The drug is used off-label for this study to manage hypophosphatemia in kidney transplant recipients.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult kidney transplant patients.
* No known contraindications to Dipyridamole

Exclusion Criteria

* Contraindications to Dipyridamole.
* Patients with delayed graft function (defined as the need for dialysis within seven days post-transplantation).
* Patients requiring Plavix, direct oral anticoagulants (DOACs), or Coumadin.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Stephan Busque

Professor of Surgery (Abdominal Transplantation)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Stephan Busque, MD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Stanford University

Stanford, California, United States

Site Status

Countries

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United States

Other Identifiers

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76830

Identifier Type: -

Identifier Source: org_study_id

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