Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome

NCT ID: NCT06814379

Last Updated: 2026-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-03

Study Completion Date

2025-07-31

Brief Summary

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More than half of patients with post-COVID-19 syndrome experience fatigue. Rehabilitation is needed to treat this persistent symptom.

The aim of this study is to conduct a rehabilitation intervention to treat patients with post-COVID-19 syndrome who experience persistent fatigue.

Detailed Description

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* Background: More than half of patients with post-COVID-19 syndrome experience fatigue. Rehabilitation is needed to treat this persistent symptom.
* Objectives: To conduct a rehabilitation intervention to treat patients with post-COVID-19 syndrome who experience persistent fatigue.
* Methodology: Randomized clinical trial. There will be 3 groups.
* Patients will be recruited from the Virgen de las Nieves University Hospital in Granada.
* The evaluation will be carried out at the University of Granada.
* The rehabilitation will be carried out at the University of Granada and/or patient's home.

Conditions

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Post-COVID-19 Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Caregivers Investigators Outcome Assessors

Study Groups

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Control group

Not intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Rehabilitation

30-60 minutes. A total of 3 session/week at home. 4 weeks.

* Warm-up.
* Aerobic: walking (20-25 minutes).
* Strength: (25-30 minutes).
* Cooling.
* Education: WHO recommendations.

Group Type EXPERIMENTAL

Rehabilitation

Intervention Type BEHAVIORAL

30-60 minutes. A total of 3 session/week at home. 4 weeks.

* Warm-up.
* Aerobic: walking (20-25 minutes).
* Strength: (25-30 minutes).
* Cooling.
* Education: WHO recommendations.

Virtual reality based rehabilitation

30-60 minutes. A total of 3 session/week (2 sessions at home and 1 session at the University of Granada). 4 weeks.

The 2 sessions at home will be the same as the sessions in the rehabilitation group (group 2).

The session at the University of Granada will be done with virtual reality (Nintendo Switch) and will follow the same outline as the rest of the sessions:

* Warm-up.
* Aerobic: walking (20-25 minutes).
* Strength: (25-30 minutes).
* Cooling.
* Education: WHO recommendations.

Group Type EXPERIMENTAL

Virtual reality based rehabilitation

Intervention Type BEHAVIORAL

30-60 minutes. A total of 3 session/week (2 sessions at home and 1 session at the University of Granada). 4 weeks.

The 2 sessions at home will be the same as the sessions in the rehabilitation group (group 2).

The session at the University of Granada will be done with virtual reality (Nintendo Switch) and will follow the same outline as the rest of the sessions:

* Warm-up.
* Aerobic: walking (20-25 minutes).
* Strength: (25-30 minutes).
* Cooling.
* Education: WHO recommendations.

Interventions

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Rehabilitation

30-60 minutes. A total of 3 session/week at home. 4 weeks.

* Warm-up.
* Aerobic: walking (20-25 minutes).
* Strength: (25-30 minutes).
* Cooling.
* Education: WHO recommendations.

Intervention Type BEHAVIORAL

Virtual reality based rehabilitation

30-60 minutes. A total of 3 session/week (2 sessions at home and 1 session at the University of Granada). 4 weeks.

The 2 sessions at home will be the same as the sessions in the rehabilitation group (group 2).

The session at the University of Granada will be done with virtual reality (Nintendo Switch) and will follow the same outline as the rest of the sessions:

* Warm-up.
* Aerobic: walking (20-25 minutes).
* Strength: (25-30 minutes).
* Cooling.
* Education: WHO recommendations.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* diagnosis of COVID-19
* post-COVID-19 syndrome
* adults ≥ 18 y \< 75 años
* be medically stable
* to be able to walk
* not currently participating in a rehabilitation programme and/or other study.
* fatigue: FSS ≥ 36 puntos
* basic knowledge
* wish to participate in the study and sign the informed consent

Exclusion Criteria

* patients with severe comorbidities that interfere with the ability to perform the study
* patients with mental, physical or organic problems that under medical criteria may pose a risk to the patient
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universidad de Granada

OTHER

Sponsor Role lead

Responsible Party

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Irene Torres Sánchez

PT, PhD, Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Irene Torres Sánchez, PhD

Role: PRINCIPAL_INVESTIGATOR

Universidad de Granada

Locations

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University of Granada

Granada, Granada, Spain

Site Status

Countries

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Spain

Other Identifiers

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COVIDATE-02

Identifier Type: -

Identifier Source: org_study_id

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