Post-stroke Seizure and Epilepsy Following Thrombolytic Therapy

NCT ID: NCT06812000

Last Updated: 2025-02-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 199 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-04-14
• Study Completion Date: 2025-01-12

Brief Summary

This retrospective cohort study was conducted by reviewing the records of consecutive patients referred to Bu Ali Sina Hospital from 2016 to 2023, who were hospitalized with a diagnosis of ischemic stroke. The records of all patients treated with intravenous alteplase during the above period were extracted, and the relevant characteristics were recorded in a questionnaire. In each year, patients with ischemic stroke who were not treated with alteplase but were hospitalized at the Bu Ali Center were selected in a similar number to patients who received alteplase in the same year, and the relevant information was extracted from their records and recorded in a questionnaire. The incidence of post-stroke seizures and epilepsy was determined in both groups, and the factors associated with their incidence were studied and compared.

Conditions

Post-stroke Seizure; Post-stroke Epilepsy; Thrombolytic (t-PA) Treatment

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Patients with ischemic stroke who received alteplase

Patients with ischemic stroke who received thrombolytic therapy with alteplase

No interventions assigned to this group

Patients with ischemic stroke who did not receive alteplase

Patients with ischemic stroke who did not receive thrombolytic therapy

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Diagnosis of ischemic stroke
• Treatment with IV alteplase

Exclusion Criteria

• History of epilepsy
• Taking antiseizure medications
• Unavailable patients
• Unreliability of recorded patients' files

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mazandaran University of Medical Sciences

OTHER

Sponsor Role: lead

Responsible Party

Nasim Tabrizi

Associate professor of neurology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Mazandaran University of Medical Sciences

Sari, Mazandaran, Iran

Countries

Iran

Other Identifiers

17989

Identifier Type: -

Identifier Source: org_study_id