EVALUATION OF SERUM INFLAMMATORY CYTOKINE CONCENTRATION IN HEREDITARY SENSITIVOMOTOR NEUROPATHIES

NCT ID: NCT06808581

Last Updated: 2025-02-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 85 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-05-04
• Study Completion Date: 2024-10-10

Brief Summary

The most common forms of hereditary neuropathy are Charcot-Marie-Tooth disease (CMT) and hereditary neuropathy with hypersensitivity to pressure (HNPP) or tomacular neuropathy. A number of patients with one of these pathologies have inflammatory infiltrates in their nerves. Although the pathophysiology has not yet been well understood, the involvement of the immune system has been discussed. Nerve hypertrophy is the main anomaly described in ultrasound in demyelinating hereditary neuropathies and to a lesser extent in axonal forms. Investigators propose to understand if there is a circulating marker of inflammation in patients with CMT or HNPP and find a correlation between the increase in plasma pro-inflammatory cytokines and ultrasound changes.

Conditions

Charcot-Marie-Tooth Disease; Hereditary Neuropathy With Hypersensitivity to Pressure

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Identify a circulating marker of inflammation in patients with CMT or HNPP

CMT = Charcot-Marie-Tooth disease HNPP = hereditary neuropathy with hypersensitivity to pressure

Group Type: EXPERIMENTAL

blood test for pro-inflammatory cytokines and ultrasound of the median nerves

Intervention Type: DIAGNOSTIC_TEST

Blood test and ultrasound

Interventions

blood test for pro-inflammatory cytokines and ultrasound of the median nerves

Blood test and ultrasound

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patient over 18 years of age
• Patient with CMT of HNPP with genetic confirmation, or acquired acute inflammatory disease such as Guillain-Barré syndrome
• Patient able to walk alone or with a walking aid.
• Patient affiliated to a social security scheme,
• Patient who has given his consent in writing after written and oral information

• Patient over 18 years of age
• Patient affiliated to a social security scheme,
• Patient who has given his consent in writing after written and oral information -

Exclusion Criteria

• Subject protected by law under guardianship or curators, or not able to participate in a clinical study under article L. 1121-16 of the French Public Health Code;
• Subject who has participated in a clinical research study during the last 3 months where he/she was exposed to a pharmaceutical product or medical device;
• Subject who has stayed in a tropical or subtropical country during the last 3 months;
• Pregnant or breastfeeding subject for women of childbearing age;
• Subject who has been physically active for less than 10 hours;
• Subject on a particular diet for medical reasons and prescribed by a doctor or dietitian (e.g., low-calorie or cholesterol-lowering diet);
• Person who regularly consumes large amounts of alcohol, i.e. more than 50 g of pure alcohol per day (for example, more than 4 glasses of wine 150 ml, more than 4 beers 250 ml, or more than 4 glasses of 40 ml containing a strong alcohol);
• Person who has used an illicit recreational drug in the last 3 months;
• Subject who has taken an immunosuppressive or immunomodulatory drug (except for intranasal or topical corticosteroids) in the last 2 weeks, or for more than 14 consecutive days in the last 6 months;
• Subject who has been vaccinated in the last 3 months;
• Subject who received a blood transfusion or immunoglobulins in the last 3 months;
• Person reporting not having fasted for at least 10 hours;
• Person reporting human immunodeficiency virus, hepatitis B virus or hepatitis C virus ;
• Subject who has had an infectious episode in the 3 weeks preceding the visit;
• Test positive for pregnancy urine;
• Subject with severe and/or chronic and/or recurrent disease
• Subject diagnosed with cancer and not in remission for more than 5 years.
• (only for patients) Other associated peripheral nerve pathology already diagnosed (inherited neuropathy or acquired neuropathy from another etiology).
• (only for Health volunteers) Presence of functional or physical signs of involvement of the median nerves, ulnar, external Sciatica Poplitea, internal Sciatica Poplitea, sural

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire de Nice

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Grasse CH

Grasse, Alpes Maritimes, France

Nice CHU

Nice, Alpes Maritimes, France

Countries

France

Other Identifiers

21-AOI-04

Identifier Type: -

Identifier Source: org_study_id