Efficacy of Novel Titania Nanoparticles Enriched Mouth Wash in Treating Dentine Hypersensitivity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

130 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-13

Study Completion Date

2024-12-03

Brief Summary

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Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50 years were allocated in two groups. Group A will use Conventional Mouth Wash without Nanoparticles. Group B will use titania nanoparticles enriched Mouth Wash. Both will use them for three months and then their VAS scoring will be checked.

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Detailed Description

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In this study Novel biogenically fabricated titania nanoparticle reinforced Mouth Wash will be evaluated for dentine sensitivity . Participants following Inclusion criteria will be allocated in this study by Consecutive random sampling technique. Participants will be divided into two groups i.e Group-A and Group-B with dentin sensitivity of 30-80. Group A will be given Conventional Mouth Wash for three months and Group-B will be given titania nanoparticles enriched Mouth Wash for three months for the sensitivity. Sensitivity will be assessed using Visual analog scale (VAS) mean score after 1 month and then three months.

Conditions

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Dentine Hypersensitivity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

In this study, participants will be allocated in two groups by Consecutive random sampling technique

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

This is a triple-blinded study in which the participant, care provider and outcome assessor will be masked

Study Groups

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Group-A: Conventional Mouth wash .

Group A will receive conventional mouthwash for treatment of dentin hypersensitivity

Group Type EXPERIMENTAL

Group- A Conventional Sensed Mouth Wash

Intervention Type PROCEDURE

In Group- A Conventional Sensed Mouth Wash will be used for treatment of Dentin hypersensitivity.

Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.

Group-B: Novel Titania nanoparticles Mouth wash

Group B will receive novel Titania nano particles reinforced mouthwash for treatment of dentin hypersensitivity

Group Type EXPERIMENTAL

Group-B Novel Titania nanoparticles enriched Mouth Wash

Intervention Type PROCEDURE

In Group-B Novel Titania nanoparticles enriched Mouth wash will be used to treat the Dentin hypersensitivity.

Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.

Interventions

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Group- A Conventional Sensed Mouth Wash

In Group- A Conventional Sensed Mouth Wash will be used for treatment of Dentin hypersensitivity.

Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.

Intervention Type PROCEDURE

Group-B Novel Titania nanoparticles enriched Mouth Wash

In Group-B Novel Titania nanoparticles enriched Mouth wash will be used to treat the Dentin hypersensitivity.

Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Participants ranging between 20-50 years, good general health but developed dentine sensitivity associated with tooth surface wear and loss during the past 6 months.
* There was no history of allergy.
* Participants did not use any mouth wash , dentifrice or medication in the last 3 months.
* The involved teeth were viable, non-shaky, devoid of any decay, cracks and fillings.
* There was an essential positive response to the provoking Air stimuli.
* These teeth should display the visible signs of tooth loss and wear such as : attrition, abrasion, erosion and abfraction.

Exclusion Criteria

* Participants that might have developed allergy or used medications during the last 2 weeks or more.
* The teeth having cracks, decay and fillings were also excluded. Patients who have undergone any periodontal surgery or gross periodontal issues.
* Participants who used any desensitisizing toothpastes/mouthwashes and tooth bleaching agents within 2 months of the trial were also excluded positively.

Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes