Accuracy of FNAC in Diagnosis of Thyroid Nodules

NCT ID: NCT06782828

Last Updated: 2025-01-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-03-31
• Study Completion Date: 2025-12-31

Brief Summary

Detection of degree of accuracy of FNAC in diagnosis of thyroid nodules

Detailed Description

Accuracy in diagnosis in any case is required, and this is beneficial to the patient and the physician, and with the development that currently exists and the trend to use less invasive techniques, accuracy of FNAC should be studied well.1.Thyroid nodules are common and the principal method of diagnosis is fine-needle aspiration cytology (FNAC).2. Can investigators depend on FNAC alone in diagnosis of thyroid nodule in the future?!3. In this study, investigators will compare the results of (FNAC) versus (Biopsy) in diagnosis of thyroid nodule in AUH , to detect the degree of accuracy of FNAC.4. FNAC is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules.5. Background Routine application of fine needle aspiration cytology (FNAC) has decreased unnecessary referral of thyroid nodules for surgical treatment and has also increased the cancer rates found in surgery materials. Success of thyroid FNAC depends on skilled aspiration, skilled cytological interpretation and rational analysis of cytological and clinical data. The aim of this study was to determine the diagnostic accuracy rates of thyroid FNAC results obtained in our hospital.6. The FNAC is a sensitive, specific, and accurate initial diagnostic test for the preoperative evaluation of patients with thyroid swellings in our setting as well. The correlation of cytological and histopathological diagnoses is an important quality assurance method, as it allows cytopathologists to calculate their false-positive and false negative results.7

Conditions

Thyroid Nodule

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

observe results of FNAC

observe results of FNAC and compare it with results of histopathological examination to detect accuracy of FNAC in diagnosis of thyroid nodules.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. thyroid disease

2. multinodular

3. single nodule

4. TIRAD 3 or more by US

5. thyroid disease underwent FNAC then surgery

6. all age groups

7. patient fit for surgery

Exclusion Criteria

1. patients with comorbidities.

2. patients unfit for surgery

3. patients who refused surgery.

4. Patient with no diagnostic FNAC.

• Minimum Eligible Age: 10 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mostafa Abed Abdulmoneim Mohammed

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Mostafa Abed Abdulmoneim Mohammed

Role: CONTACT

mostafaabed1417@gmail.com

01142799359

References

Poller DN, Stelow EB, Yiangou C. Thyroid FNAC cytology: can we do it better? Cytopathology. 2008 Feb;19(1):4-10. doi: 10.1111/j.1365-2303.2007.00492.x. Epub 2007 Oct 3.

Reference Type: BACKGROUND

PMID: 17916090 (View on PubMed)

Bhise SV, Shaikh A, Hippargekar PM, Kothule S. A Prospective Study of Ultrasonographic and FNAC Correlation of Thyroid Swellings with Histopathology. Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):1942-1948. doi: 10.1007/s12070-020-01922-w. Epub 2020 Jun 24.

Reference Type: BACKGROUND

PMID: 36452634 (View on PubMed)

Momin MA, Bhuiyan FU, Chakraborty S, Kar NK. FNAC and Its Utility in Solitary Thyroid Nodule and Its Correlation with Histopathological Examination. Mymensingh Med J. 2019 Apr;28(2):356-363.

Reference Type: BACKGROUND

PMID: 31086151 (View on PubMed)

Other Identifiers

FNAC in thyroid nodules

Identifier Type: -

Identifier Source: org_study_id