Deep Core Muscles and Biopsychosocial in Asymptomatic Adults and NSCLBP

NCT ID: NCT06782633

Last Updated: 2025-01-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 57 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-08-01
• Study Completion Date: 2024-08-30

Brief Summary

The goal of this observational study is to (1) investigate age effects on core muscles, sensorimotor system, psychosocial factors in asymptomatic adults across years of age; (2) explore the differences in biopsychosocial factors between asymptomatic adults and people with non-specific chronic low back pain (NSCLBP); (3) study the correlations between biopsychosocial factors in people with NSCLBP.

The main questions it aims to answer :

1. Are the core muscles, lumbar propriocpetion, and psychological measures altered as age increases?

2. Do the core muscles, lumbar propriocpetion, functional performance, psychological measures, disability, and quality of life affected by NSCLBP?

3. following (2), if so, are there correlations between the measured biopsychosocial factors, disability, and quality of life in people with NSCLBP?

Researchers will compare between people with NSCLBP and age-matched asymptomatic participants across years of age to see if the effect of age and effect of NSCLBP existed in biopsychosocial factors.

Participants will

1. be observed by ultrasound image at the low back and abdominal areas to collect parameters related to trunk deep core muscles, such as changes in muscle thickness from resting state to contraction;

2. ungergo MRI examination to acquire image of deep core muscles;

3. perform lumbar repositioning test which quantifies the lumbar proprioception;

4. perform Timed Up-and-Go Test and Five-Times Sit-to-Stand test, which are used as a measurement of physically functional performance;

5. fill out the psychosocial questionnaires including: Patient-Reported Outcomes Measurement Information System Short Form Depression 4a and Anxiety 4a, Pittsburgh Sleep Quality Index, Pain Catastrophizing Scale, Fear-Avoidance Belief Questionnaire, Oswestry Disability Index, and Heath Survey Short Form-36.

Conditions

Non-Spesific Chronic Low Back Pain; Aged

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

non-specific chronic low back pain

Participants with non-specific chronic low back pain (CLBP) aged 20-65 years old were recruited from the community by posters. Non-specific chronic low back was defined as discomfort in the low back area, which persisted over a day during the past three months and was diagnosed as non-specific low back pain. Participants who 1) had gone through surgery at the low back or lower extremity; 2) presented neurological symptoms, such as numbness or tingling; 3) could not walk or stand independently; 4) had cancer; 5) had systemic inflammation, such as ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus; 6) were in pregnancy were excluded from the study.

No interventions assigned to this group

Asymptomatic

Asymptomatic participants aged 20-65 years old were recruited from the community by posters. Participants who 1) had gone through surgery at the low back or lower extremity; 2) presented neurological symptoms, such as numbness or tingling; 3) could not walk or stand independently; 4) had cancer; 5) had systemic inflammation, such as ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus; 6) were in pregnancy were excluded from the study.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• aged above 20 years old
• Non-specific chronic low back defined as discomfort in the low back area, which persisted over a day during the past three months and was diagnosed as non-specific low back pain.

Exclusion Criteria

• history of surgery at the low back or lower extremity
• neurological symptoms, such as numbness or tingling
• not able to walk or stand independently
• cancer
• systemic inflammation, such as ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus
• in pregnancy

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Science and Technology Council

FED

Sponsor Role: collaborator

National Taiwan University

OTHER

Sponsor Role: collaborator

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

School and Graduate Institute of Physical Therapy, National Taiwan University

Taipei, , Taiwan

Countries

Taiwan

Other Identifiers

MOST 111-2221-E-002-059

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

MOST 112-2221-E-002-092

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

202012268RIND

Identifier Type: -

Identifier Source: org_study_id