Epidemiology of Abdominal Aortic Aneurysm With Concomitant Primary Lung Cancer

NCT ID: NCT06775821

Last Updated: 2025-01-15

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-10-01
• Study Completion Date: 2025-04-30

Brief Summary

Retrospective clinical case studies in recent years have shown that most cases of lung cancer and abdominal aortic aneurysm (AAA) are detected at the same time and that there is a wide variation in the prevalence of AAA in patients with primary lung cancer reported in the literature, with some papers suggesting as high as 11%, suggesting that there may be a relationship between the prevalence of the two diseases. However, its exact incidence and mechanism are unknown. Accurate prevention of AAA in patients with primary lung cancer requires more in-depth studies. To solve the above problems, a multi-center prospective epidemiological investigation and mechanism study on the association of AAA in primary lung cancer combined has become particularly urgent. The results of the study will be of great significance for the follow-up treatment and prognosis of lung cancer patients as well as the improvement of long-term survival rate of lung cancer patients, and will also provide scientific basis and clinical guidance for the screening and prevention of AAA in lung cancer patients.

Detailed Description

1. research purpose： This study collected detailed basic information, lifestyle habits, past medical history, and laboratory indicators from 2000-3000 outpatient patients with primary lung cancer for data analysis and long-term follow-up. The study analyzed the related factors of lung cancer complicated with AAA, providing direct scientific evidence to better guide lung cancer patients in screening for AAA, identifying common high-risk factors for lung cancer patients complicated with AAA, providing clinical guidance for the prevention of AAA, and reducing the risk of AAA rupture. The research results are of great significance for the subsequent treatment and prognosis of lung cancer patients, as well as improving the long-term survival rate of lung cancer patients. They will also provide scientific basis and clinical guidance for the screening and prevention of AAA in lung cancer patients. Early detection and treatment of AAA can reduce the risk of AAA rupture, greatly improve the prognosis of lung cancer patients with AAA, and enhance their quality of life.

2. research population： The research subjects are patients diagnosed with primary lung cancer at the Third Affiliated Hospital of Kunming Medical University and the First Affiliated Hospital of Kunming Medical University from 1st October 2022 to 30 st April 2025. The expected sample size is about 2000 people, and the age of patients is 20-90 years old. Collect detailed epidemiological data and long-term follow-up data, conduct statistical analysis, and conduct epidemiological investigations.

3. Epidemiological data collection:

3.1 Basic Information: name, gender, ethnicity, age, height, weight, hometown, occupation, education level, ID card, phone number, and medical record number.

3.2 Behavioral Life Information：Whether smoking, smoking index, alcohol consumption, alcohol content and quantity consumed, history of exposure to asbestos products, dietary habits, and history of dust exposure.

3.3 Past medical history and family genetic history: Presence of hypertension, degree of hypertension, blood pressure control medications, and blood pressure control; diabetes mellitus, blood glucose control medications, and blood glucose control; hyperlipidemia, elevated lipid composition, lipid control medications, and lipid control; urologic disorders; family history of vascular disorders; and family history of oncologic disorders.

3.4 Laboratory information: Blood pressure, fasting blood glucose, glycosylated hemoglobin Total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C).

3.5 Follow-up information:

1. Information related to primary lung cancer: types of lung tumors (squamous cell carcinoma, adenocarcinoma, small cell/neuroendocrine/other); Staging of lung tumors (stages I, II, III, IV); CNM staging; Differentiation results of lung tumors; Immunohistochemical staining results; Tumor markers (outliers); Tumor genes (outliers); The treatment methods for lung tumors (surgery, radiotherapy, chemotherapy, molecular targeting, immunity, biological therapy, neoadjuvant chemotherapy); Surgical time and bleeding volume.

2. Information related to abdominal aortic aneurysm: whether it is complicated with abdominal aortic aneurysm; Is there a concomitant iliac artery aneurysm; Whether to undergo surgical treatment; Surgical treatment methods (endovascular repair of abdominal aortic aneurysm, open surgery); Surgical time and bleeding volume.

3. Patient prognosis: last follow-up time, time of lung tumor recurrence, whether death occurred, and cause of death.

4.Data entry and analysis At the Department of Thoracic Surgery of the First Affiliated Hospital of Kunming Medical University and the Department of Thoracic Surgery of the Third Affiliated Hospital of Kunming Medical University, patient basic information, laboratory tests, and treatment plans are obtained and filled out from the hospital's medical record system. Epidemiological survey questions are collected at the patient's bedside using a question and answer format to ensure the accuracy and reliability of the epidemiological survey information. All collected data is organized and encoded using REDCap（ https://www.wcrcnet.cn/redcap/ ）Perform data entry. IBM SPSS Statistics 22 will be used to analyze the entered data and identify the risk factors for primary lung cancer combined with AAA.

Conditions

Abdominal Aortic Aneurysm; Primary Lung Cancer; Prevalence

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Primary lung cancer with concomitant abdominal aortic aneurysm

Ultrasound or CT of the abdominal aorta

Intervention Type: DEVICE

Patient underwent ultrasound or CT of the abdominal aorta

Interventions

Ultrasound or CT of the abdominal aorta

Patient underwent ultrasound or CT of the abdominal aorta

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Patients diagnosed with primary lung cancer through clinical or pathological examination

Exclusion Criteria

• Patients diagnosed with primary lung cancer who refuse to undergo abdominal aortic imaging screening.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Third Affiliated Hospital of Kunming Medical University

UNKNOWN

Sponsor Role: collaborator

Kunming Medical University

OTHER

Sponsor Role: collaborator

First Affiliated Hospital of Kunming Medical University

OTHER

Sponsor Role: lead

Responsible Party

Dr. Kai-Xiong QING

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xu-Dong Xiang, MPhil

Role: STUDY_DIRECTOR

The Third Affiliated Hospital of Kunming Medical University

Ding-yun You, Ph.D.

Role: STUDY_DIRECTOR

Kunming Medical University

Yun-fei Shi, MPhil

Role: STUDY_DIRECTOR

First Affiliated Hospital of Kunming Medical University

Gui-ming Liu, MBBS

Role: PRINCIPAL_INVESTIGATOR

The Third Affiliated Hospital of Kunming Medical University

Qing-yan Ma, MBBS

Role: PRINCIPAL_INVESTIGATOR

Kunming Medical University

Qian Zhu, MBBS

Role: PRINCIPAL_INVESTIGATOR

The Third Affiliated Hospital of Kunming Medical University

Kai-xiong Qing, ph.D.

Role: STUDY_CHAIR

The Third Affiliated Hospital of Kunming Medical University

Locations

The First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Site Status: RECRUITING

The Third Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Kai-xiong Qing, Ph.D.

Role: CONTACT

davidqkx@gmail.com

15908855311

Qian Zhu, MBBS

Role: CONTACT

zhuqian0711@163.com

15191066760

Facility Contacts

Yun-fei shi, Mphil

Role: primary

13908716639

Xu-dong Xiang, MPhil

Role: primary

13108519813

References

Sakalihasan N, Michel JB, Katsargyris A, Kuivaniemi H, Defraigne JO, Nchimi A, Powell JT, Yoshimura K, Hultgren R. Abdominal aortic aneurysms. Nat Rev Dis Primers. 2018 Oct 18;4(1):34. doi: 10.1038/s41572-018-0030-7.

Reference Type: BACKGROUND

PMID: 30337540 (View on PubMed)

Schanzer A, Oderich GS. Management of Abdominal Aortic Aneurysms. N Engl J Med. 2021 Oct 28;385(18):1690-1698. doi: 10.1056/NEJMcp2108504. No abstract available.

Reference Type: BACKGROUND

PMID: 34706173 (View on PubMed)

Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019 Apr;16(4):225-242. doi: 10.1038/s41569-018-0114-9.

Reference Type: BACKGROUND

PMID: 30443031 (View on PubMed)

Alnahhal KI, Urhiafe V, Narayanan M, Irshad A, Salehi P. Prevalence of abdominal aortic aneurysms in patients with lung cancer. J Vasc Surg. 2022 May;75(5):1577-1582.e1. doi: 10.1016/j.jvs.2021.09.037. Epub 2021 Oct 8.

Reference Type: RESULT

PMID: 34634421 (View on PubMed)

Wiles B, Comito M, Labropoulos N, Santore LA, Bilfinger T. High prevalence of abdominal aortic aneurysms in patients with lung cancer. J Vasc Surg. 2021 Mar;73(3):850-855. doi: 10.1016/j.jvs.2020.05.069. Epub 2020 Jul 2.

Reference Type: RESULT

PMID: 32623102 (View on PubMed)

Cho HJ, Yoo JH, Kim MH, Ko KJ, Jun KW, Han KD, Hwang JK. Risk of various cancers in adults with abdominal aortic aneurysms. J Vasc Surg. 2023 Jan;77(1):80-88.e2. doi: 10.1016/j.jvs.2022.03.896. Epub 2022 Jul 15.

Reference Type: RESULT

PMID: 35850163 (View on PubMed)

Hohneck A, Shchetynska-Marinova T, Ruemenapf G, Pancheva M, Hofheinz R, Boda-Heggemann J, Sperk E, Riffel P, Michels J, Borggrefe M, Akin I, Sigl M. Coprevalence and Incidence of Lung Cancer in Patients Screened for Abdominal Aortic Aneurysm. Anticancer Res. 2020 Jul;40(7):4137-4145. doi: 10.21873/anticanres.14413.

Reference Type: RESULT

PMID: 32620663 (View on PubMed)

Harthun NL, Lau CL. The incidence of pulmonary neoplasms discovered by serial computed tomography scanning after endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2011 Mar;53(3):738-41. doi: 10.1016/j.jvs.2010.09.066. Epub 2010 Dec 3.

Reference Type: RESULT

PMID: 21129909 (View on PubMed)

Lederlin M, Tredaniel J, Priollet P. [Why screen for lung cancer in patients with arterial disease?]. J Mal Vasc. 2015 Dec;40(6):359-64. doi: 10.1016/j.jmv.2015.07.001. Epub 2015 Aug 12. French.

Reference Type: RESULT

PMID: 26276562 (View on PubMed)

Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwoger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ; ESC Committee for Practice Guidelines. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J. 2014 Nov 1;35(41):2873-926. doi: 10.1093/eurheartj/ehu281. Epub 2014 Aug 29. No abstract available.

Reference Type: RESULT

PMID: 25173340 (View on PubMed)

Scorza R, Ghilardi G, De Monti M, Sgroi G. [Current knowledge and unresolved problems in the pathogenesis of abdominal aortic aneurysm]. Minerva Cardioangiol. 1994 Sep;42(9):417-27. Italian.

Reference Type: RESULT

PMID: 7991161 (View on PubMed)

Provided Documents

Document Type: Informed Consent Form

View Document

Other Identifiers

CALUNGAAA

Identifier Type: -

Identifier Source: org_study_id