Prognostic Significance of the Lung Immune Prognostic Index (LIPI) in Postoperative Clear Cell Renal Cell Carcinoma: a Multicenter Retrospective Cohort Study

NCT ID: NCT06775574

Last Updated: 2025-01-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 704 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-11-01
• Study Completion Date: 2023-09-30

Brief Summary

This retrospective study included 704 patients with ccRCC who underwent radical or partial nephrectomy. Patients were stratified into the LIPI good group and the intermediate/poor (int./poor) group based on dNLR (≥ 3) and LDH (≥ 245 U/L) levels. Propensity score matching (PSM) was used to adjust for baseline differences and minimize selection bias. Kaplan-Meier survival curves and Cox regression models were employed to evaluate the impact of LIPI and other clinical factors on recurrence-free survival (RFS) and overall survival (OS).

Conditions

ccRCC

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Cohort 1

Patients with dNLR \< 3 and LDH levels below the upper limit of normal

No interventions assigned to this group

Cohort 2

Patients with dNLR ≥ 3 and LDH levels above the upper limit of normal

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Pathologically diagnosed with ccRCC;

2. Underwent radical or partial nephrectomy.

Exclusion Criteria

1. presence of concurrent malignancies;

2. missing data or failure to follow-up

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Wuhan Union Hospital

Wuhan, Hubei, China

Countries

China

Other Identifiers

0361-01

Identifier Type: -

Identifier Source: org_study_id