A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC

NCT ID: NCT06769295

Last Updated: 2025-01-10

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-01
• Study Completion Date: 2027-12-31

Brief Summary

This is a phase II study. All patients are stage IV non-squamas non-small cell lung cancer(NSCLC) with malignant pleura effusion, Eastern Cooperative Oncology Group (ECOG) performance status 0-2. The purpose of this study is to evaluate the efficacy and safety of AK112 in combination with chemotherapy in patients with NSCLC with malignant pleura effusion.

Conditions

Lung Cancer, Non-Small Cell

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

non-Squamous NSCLC with MPE:AK112 plus Chemotherapy

non-Squamous NSCLC with malignant pleura effusions:Subjects receive AK112 plus Pemetrexed/Taxol and Carboplatin/Cispaltin on Day 1 of every 3-week cycle (Q3W) for 4 cycles followed by AK112 plus Pemetrexed until progression.

Group Type: EXPERIMENTAL

AK112

Intervention Type: DRUG

non-Squamous NSCLC with malignant pleura effusions:Subjects receive AK112 plus Pemetrexed and Carboplatin/Cisplatin on Day 1 of every 3-week cycle (Q3W) for 4 cycles followed by AK112 plus Pemetrexed until progression.

Interventions

AK112

non-Squamous NSCLC with malignant pleura effusions:Subjects receive AK112 plus Pemetrexed and Carboplatin/Cisplatin on Day 1 of every 3-week cycle (Q3W) for 4 cycles followed by AK112 plus Pemetrexed until progression.

Intervention Type: DRUG

Other Intervention Names

Pemetrexed; Carboplatin/Cisplatin

Eligibility Criteria

Inclusion Criteria

• 18 to 75 years old (at the time of inform consent obtained)；
• Have histologically- or cytologically-confirmed diagnosis of Stage IV non-squamas NSCLC；
• The presence of malignant pleural effusion (positive pleural effusion cytology or multiple pleural nodules or thickening with pleural effusion on CT imaging)；
• Driver gene mutation negative；
• Have a life expectancy of at least 3 months；
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2；
• Has adequate organ function；
• Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 assessed by investigator；
• Be able to provide formalin fixed, paraffin-embedded (FFPE) tumor tissue obtained from either a core or excisional tumor biopsy；
• All female and male subjects of reproductive potential must agree to use an effective method of contraception, as determined by the Investigator, during and for 120 days after the last dose of study treatment；
• Be able and willing to provide written informed consent and to comply with all requirements of study participation (including all study procedures).

Exclusion Criteria

• Histological or cytological pathology confirmed the presence of small cell carcinoma components, or the main component is squamous cell carcinoma；
• Active malignancies within the past 3 years, with the exception of tumors in this study and cured local tumors；
• Is currently participating in a study of an investigational agent or using an investigational device;
• Active autoimmune disease requiring systemic treatment within 2 years prior to the start of study treatment；
• Subjects who received any prior treatments targeting VEGFR;
• Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA [qualitative] is detected);
• History of myocardial infarction, unstable angina, cardiac or other vascular stenting, angioplasty, or surgery within 12 months prior to day 1 of study treatment;
• Has undergone major surgery within 30 days prior to the first dose of study treatment;
• Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment NOTE: Subjects with vitiligo or resolved childhood asthma/atopy would be an exception to this rule. Subjects that require intermittent use of bronchodilators or local steroid injections would not be excluded from the study;
• Has received a live virus vaccine within 30 days prior to first dose of study treatment；

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sichuan University

OTHER

Sponsor Role: lead

Responsible Party

Yongsheng Wang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yongsheng Wang, Prof

Role: PRINCIPAL_INVESTIGATOR

West China Hospital

Locations

West China Hospital, Sichuan University

Chengdu, Sichuan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Ge Gao, PhD

Role: CONTACT

gg1023@foxmail.com

86（028）85421606

Facility Contacts

Ge Gao, PhD

Role: primary

gg1023@foxmail.com

86（028）85421606

Yongsheng Wang, Prof

Role: backup

Ge Gao, PhD

Role: backup

Other Identifiers

HX-AK112-01

Identifier Type: -

Identifier Source: org_study_id