Neoadjuvant Therapy of Sintilimab Combined With Chemotherapy for Resectable Squamous Cell NSCLC（neoSCORE Ⅱ）

NCT ID: NCT05429463

Last Updated: 2022-12-14

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 250 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-11-11
• Study Completion Date: 2029-11-11

Brief Summary

This is a Phase 3, prospective, randomized, open-label, multi-center study that assesses the efficacy and safety of neoadjuvant therapy with different cycles of sintilimab combined with chemotherapy for Resectable Squamous Cell NSCLC. This trial will also explore the biomarkers of neoadjuvant immunochemotherapy.

Detailed Description

This is a Phase 3, prospective, randomized, open-label, multi-center study that assesses the efficacy and safety of neoadjuvant therapy with different cycles of sintilimab combined with chemotherapy for Resectable Squamous Cell NSCLC. In this trial, eligible subjects will be randomly assigned to arm A and arm B (1:1). Subjects in arm A will receive 3 cycles of neoadjuvant sintilimab with chemotherapy and arm B will receive 4 cycles of neoadjuvant sintilimab with chemotherapy, followed by surgery within the 3-5th week after the last dose of sintilimab. After operation, both subjects in arm A and B can receive the treatment of sintilimab for up to 1 year according to the requirements of patients. The primary purpose is MPR rate of Resectable Squamous Cell NSCLC with different cycles of sintilimab combined with chemotherapy, which is defined as the percentage of participants having ≤10% viable tumor cells in the pathological examination of resected specimens.

Conditions

Squamous Cell Non-small Cell Lung Cancer

Keywords

Sintilimab; Squamous Cell NSCLC; Neoadjuvant immunochemotherapy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm A(3 cycles of neoadjuvant therapy)

Neoadjuvant: Prior to surgery, participants receive up to 3 cycles (cycle length: 3 weeks) of sintilimab [200 mg, intravenous (IV); given on cycle day 1] in combination with neoadjuvant chemotherapy, consisting of albumin-bound paclitaxel [260 mg/m^2, IV; given on cycle day 1] and carboplatin [AUC 5- 6mg/mL/min, IV; given on cycle day 1 ] .

Adjuvant: Followed by surgery within the 3-5th week after the last dose of sintilimab, the researcher will decide whether to radiotherapy or not according to the clinical situation and pathological stage of the patient. The maintenance treatment of sintilimab [200 mg, intravenous (IV); given on cycle day 1; cycle length: 3 weeks] may be selected upon subject request for up to 1 year.

Group Type: EXPERIMENTAL

Sintilimab

Intervention Type: BIOLOGICAL

200 mg by IV infusion every 3 weeks (Q3W), given on cycle day 1.

Carboplatin

Intervention Type: DRUG

AUC 5-6 mg/mL/min by IV infusion Q3W, given on cycle day 1.

Albumin-Bound Paclitaxel

Intervention Type: DRUG

260 mg/m\^2 by IV infusion Q3W, given on cycle day 1.

Arm B(4 cycles of neoadjuvant therapy)

Neoadjuvant: Prior to surgery, participants receive up to 4 cycles (cycle length: 3 weeks) of sintilimab [200 mg, intravenous (IV); given on cycle day 1] in combination with neoadjuvant chemotherapy, consisting of albumin-bound paclitaxel [260 mg/m^2, IV; given on cycle day 1] and carboplatin [AUC 5- 6mg/mL/min, IV; given on cycle day 1 ] .

Adjuvant: Followed by surgery within the 3-5th week after the last dose of sintilimab, the researcher will decide whether to radiotherapy or not according to the clinical situation and pathological stage of the patient. The maintenance treatment of sintilimab [200 mg, intravenous (IV); given on cycle day 1; cycle length: 3 weeks] may be selected upon subject request for up to 1 year.

Group Type: EXPERIMENTAL

Sintilimab

Intervention Type: BIOLOGICAL

200 mg by IV infusion every 3 weeks (Q3W), given on cycle day 1.

Carboplatin

Intervention Type: DRUG

AUC 5-6 mg/mL/min by IV infusion Q3W, given on cycle day 1.

Albumin-Bound Paclitaxel

Intervention Type: DRUG

260 mg/m\^2 by IV infusion Q3W, given on cycle day 1.

Interventions

Sintilimab

200 mg by IV infusion every 3 weeks (Q3W), given on cycle day 1.

Intervention Type: BIOLOGICAL

Carboplatin

AUC 5-6 mg/mL/min by IV infusion Q3W, given on cycle day 1.

Intervention Type: DRUG

Albumin-Bound Paclitaxel

260 mg/m\^2 by IV infusion Q3W, given on cycle day 1.

Intervention Type: DRUG

Other Intervention Names

IBI308; PD-1 antibody

Eligibility Criteria

Inclusion Criteria

1. Sign the informed consent form before starting any trial related procedure.Be willingness and able to undergo planned visits, protocol therapy, laboratory tests and other testing procedures.

2. 18-75 years old, male or female.

3. Squamous Cell Non-small cell lung cancer confirmed by cytology or histology.

4. There must be at least one evaluable focus judged according to recist1.1 standard.

5. Evaluation by the researchers and classified by the 8th version of AJCC TNM staging to confirm resectable stage cⅡA-ⅢB squamous NSCLC patients without any treatment before.

6. ECOG PS 0-1.

7. Life expectancy > 6 months.

8. Adequate organ function and it should meet the following criteria:

Absolute value of neutrophils (ANC) ≥1.5×109/L in the absence of granulocyte colony stimulating factor for the past 14 days; Platelet ≥100×109/L in the last 14 days without blood transfusion; Hemoglobin >9g/dL in the absence of blood transfusion or erythropoietin in the last 14 days ;

Total bilirubin(TBIL)≤1.5ULN, ALT、AST≤ 2.5 ULN, serum creatinine(sCr)≤1.5ULN;

Good blood coagulation: INR≤1.5 or PT≤1.5 ULN;

Normal thyroid function: TSH within normal institutional limits;

9. For women of reproductive age, a urine or serum pregnancy test with negative results should be performed within 3 days prior to receiving the first study drug administration (day 1 of cycle 1). If a urine pregnancy test result cannot be confirmed as negative, a blood pregnancy test is requested. Women of nonreproductive age were defined as at least 1 year after menopause or having undergone surgical sterilization or hysterectomy. If there is a risk of conception, all subjects (both men and women) will use a medically approved highly effective contraceptive (e.g., an intrauterine device, birth control pill, or condom) for the entire treatment period up to 120 days after the last study drug (or 180 days after the last chemotherapy drug).

Exclusion Criteria

1. Malignancies within 5 years prior to the first dose(excluding radical skin basal cell carcinoma, skin squamous cell carcinoma and / or radical resection of carcinoma in situ).

2. Currently participating in the intervention clinical treatment, or receiving other drugs or research instruments within 4 weeks before the first dose.

3. Patients who have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or drugs for another stimulation or synergistic inhibition of T cell receptor (e.g. CTLA-4, OX-40, CD137).

4. Active autoimmune diseases requiring systemic treatment (e.g. using disease improving drugs, corticosteroids or immunosuppressants) occurred within 2 years before the first dose. Alternative therapies (e.g. thyroxine, insulin or corticosteroids in physiological doses for adrenal or pituitary insufficiency) are not considered systemic treatment.

5. Systemic glucocorticoid therapy (excluding local glucocorticoids by nasal spray, inhalation or other routes) or any other form of immunosuppressive therapy is in progress within 7 days before the first dose.

Note: it is allowed to use physiological dose of glucocorticoid (Prednisone≤10 mg/d or equivalent drug).

6. Received allogeneic organ transplantation (except corneal transplantation) or allogeneic hematopoietic stem cell transplantation.

7. Allergic to study drug(sintilimab, carboplatin, albumin-bound paclitaxel) components excipients.

8. Not fully recovered from toxicity and/ or complications caused by any intervention before treatment (≤level 1 or reach baseline, excluding fatigue or hair loss).

9. Has a known history of human immunodeficiency virus (HIV) infection (HIV 1/2 antibody positive).

10. Untreated active Hepatitis B (defined as HBsAg positive and HBV-DNA copies>ULN).

11. Active Hepatitis C (HCV antibody positive and HCV-RNA level higher than the detection limit).

12. Inoculate the live vaccine within 30 days before the first dose (cycle 1 day 1).

Note: it is allowed to receive the injection inactivated virus vaccine for seasonal influenza within 30 days before the first dose; however, it is not allowed to accept the live attenuated influenza vaccine for intranasal medication.

13. Pregnant or lactating women.

14. There are any serious or uncontrollable systemic diseases, such as:

Resting ECG has significant abnormalities in rhythm, conduction or morphology, and the symptoms are serious and difficult to control,such as complete left bundle branch block, heart block above degree Ⅱ, ventricular arrhythmia or atrial fibrillation;

Unstable angina, congestive heart failure, chronic heart failure with NYHA grade ≥ 2;

Within 6 months before inclusion, there were any arterial thrombosis, embolism or ischemia, such as myocardial infarction, unstable angina, cerebrovascular accident, transient ischemic attack etc;

History of noninfectious pneumonia requiring glucocorticoid treatment within 1 year before the first dose,or having currently clinical active interstitial lung diseases;

Active pulmonary tuberculosis;

Active or uncontrolled infections requiring systemic treatment;

Liver diseases such as cirrhosis, decompensated liver disease, acute or chronic active hepatitis;

Poorly controlled diabetes (Fasting blood glucose (FBG)>10mmol/L);

Urine routine test indicates that urine protein≥++, and confirmed that 24 hours proteinuria>1.0 g;

Patients with mental disorders who are unable to cooperate with the treatment;

15. There are medical history, disease, treatment or laboratory abnormal results that may interfere with the test results, prevent the subjects from participating in the whole process of the study, or the researchers think that participating in the study is not in the best interests of the subjects or there are other potential risks that the subjects are not suitable for the study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

Site Status: RECRUITING

Countries

China

Central Contacts

Fuming Qiu

Role: CONTACT

Phone: 13858005908

Email: qiufuming@zju.edu.cn

Facility Contacts

Fuming Qiu, PhD

Role: primary

References

Zhang X, Shao M, Yao J, Zhao L, Li L, Chen M, Zhang Y, Liu H, Chen Z, Li B, Wu Z, Fan J, Qiu F. NeoSCORE II: three vs four cycles of neoadjuvant sintilimab + chemotherapy for squamous non-small-cell lung cancer. Future Oncol. 2024 Jan;20(3):121-129. doi: 10.2217/fon-2024-0026. Epub 2024 Feb 14.

Reference Type: DERIVED

PMID: 38353107 (View on PubMed)

Other Identifiers

neoSCORE Ⅱ

Identifier Type: -

Identifier Source: org_study_id