Tissue Quality of Integra vs. BTM Treated Burns

NCT ID: NCT06760611

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-01

Study Completion Date

2025-09-30

Brief Summary

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An observational analysis of Integra-treated burns and Novosorb Biodegradable Temporizing Matrix (BTM)-treated burns will be undertaken 12-36 months post final skin graft application by retrospectively analyzing the patient's electronic medical record, and prospectively using a non-invasive measures of tissue quality and patient-reported outcomes. Patients will be offered the option to consent for a tissue biopsy for pathological evaluation.

Detailed Description

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Conditions

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Burn Injury Burn Scar Burn Wounds - Partial Thickness (2nd Degree) Skin Grafting

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Integra Cohort

Patient with a burn treated with Integra® in conjunction with standard of care (SOC)\* 12-36 months post final skin graft application. 25 unique cases will be enrolled into this group.

No interventions assigned to this group

BTM Cohort

Patient with a burn treated with BTM in conjunction with SOC\* 12-36 months post- skin graft application. 25 unique cases will be enrolled into this group.

No interventions assigned to this group

Combination Cohort

Patient with a burn treated with Integra and BTM in different regions of the body in conjunction with SOC\* 12-36 months post-skin graft application. Up to 10 unique cases can be enrolled into this group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Patient has reviewed the IRB-approved consent form, has been properly consented per the protocol and has documented their consent to participate in the study by signing the IRB-approved consent form.
2. Patient had a deep dermal or full-thickness burn that required skin grafting that was first treated with Integra\* or BTM, and at least 70% 'take' followed by an autograft
3. Patient had final skin graft between 12-36 months prior enrollment in the study.
4. Burn must have been ≥10% total body surface area (TBSA) and ≤70% TBSA.
5. Patient is ≥ 21 years of age at the time of treatment.

Exclusion Criteria

1. Patient had a radiation burn.
2. Patient was treated with Integra or BTM and closed via secondary intention.
3. Severe cognitive dysfunction or psychiatric disorders.
4. Immunocompromised patients.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Integra LifeSciences Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yi Arnold

Role: STUDY_DIRECTOR

Medical Affairs

Other Identifiers

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T-IDRTTQ-001

Identifier Type: -

Identifier Source: org_study_id

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