Study of Pneumococcal Carriage in RSV Bronchiolitis in Infants Aged 6 to 18 Months
NCT ID: NCT06722716
Last Updated: 2025-05-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
120 participants
OBSERVATIONAL
2025-10-31
2026-02-28
Brief Summary
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Detailed Description
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Furthermore, the carriage rate of S. pneumoniae in infants under 2 years of age in healthy populations is described as around 25%. In the case of RSV infection, this rate rises to 50%. Some data from animal models have shown that RSV infection increases S. pneumoniae transmission within a group of individuals, partly explaining this difference. However, data remain limited, particularly in human samples, and further research is needed to better understand the role of the RSV-pneumococcal relationship in the occurrence of severe RSV infections (pneumonia) and invasive pneumococcal infections. This study will examine pneumococcal carriage in bronchiolitis in infants aged 6-18 months, through nasopharyngeal swabs from infants with bronchiolitis and healthy infants. Pneumococcal carriage rates and serotype profiles will be investigated.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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bronchiolitis group
Nasopharyngeal swab
Swab collection
Nasopharyngeal swab
healthy group
Infants without RSV bronchiolitis
Swab collection
Nasopharyngeal swab
Interventions
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Swab collection
Nasopharyngeal swab
Eligibility Criteria
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Inclusion Criteria
* With bronchiolitis during RSV epidemic season (bronchiolitis group) or without evidence of RSV viral infection (healthy group)
* No chronic illness
* No history of bronchiolitis
* Signed consent from parents or legal guardians
* Patient affiliated to a social security scheme
Exclusion Criteria
* Medical history of bronchiolitis or newborn asthma
* Treatment with immunosuppressants
* Patient on AME
6 Months
18 Months
ALL
Yes
Sponsors
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National Pneumococcal Reference Center
UNKNOWN
Infectious Diseases Models for Innovative Therapies
UNKNOWN
Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Locations
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Hôpital Antoine Béclère
Clamart, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-A01592-45
Identifier Type: OTHER
Identifier Source: secondary_id
APHP240862
Identifier Type: -
Identifier Source: org_study_id
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