A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

NCT ID: NCT06717425

Last Updated: 2025-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

263 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-12-09

Study Completion Date

2025-11-27

Brief Summary

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The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolerate the study medicine.

Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This is a randomized, double-blind (investigator and participant), sponsor-open, placebo-controlled study.
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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PF-07976016 Dose 1

Group Type EXPERIMENTAL

PF-07976016

Intervention Type DRUG

Taken once daily

PF-07976016 Dose 2

Group Type EXPERIMENTAL

PF-07976016

Intervention Type DRUG

Taken once daily

PF-07976016 Dose 3

Group Type EXPERIMENTAL

PF-07976016

Intervention Type DRUG

Taken once daily

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Taken once daily

Interventions

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PF-07976016

Taken once daily

Intervention Type DRUG

Placebo

Taken once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or non-pregnant, non-breastfeeding female, 18 to 74 years of age at Visit 1
* Body Mass Index ≥30.0 kg/m2 at Visit 1, with stable body weight, defined as \<5 kg change in the 12 weeks before Visit 1
* Eligible and willing to receive required background medicine
* Willing and able to comply with all study procedures

Exclusion Criteria

* Any medical or psychiatric condition or laboratory abnormality, or recent serious illness or hospitalization, that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study including diagnosis of type 2 diabetes mellitus, type 1 or secondary forms of diabetes.
* Use of any prohibited prior or concomitant medication(s)
* Presence of specified abnormalities on diagnostic assessments including clinical laboratory tests at Visit 1.
Minimum Eligible Age

18 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Anaheim Clinical Trials, LLC

Anaheim, California, United States

Site Status

Artemis Institute for Clinical Research

San Diego, California, United States

Site Status

Clinical & Translational Research Center

Aurora, Colorado, United States

Site Status

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Site Status

Westside Center for Clinical Research

Jacksonville, Florida, United States

Site Status

New Horizon Research Center

Miami, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

St Johns Center for Clinical Research

Saint Augustine, Florida, United States

Site Status

Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, United States

Site Status

East-West Medical Research Institute

Honolulu, Hawaii, United States

Site Status

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, United States

Site Status

L-MARC Research Center

Louisville, Kentucky, United States

Site Status

Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Site Status

StudyMetrix Research

City of Saint Peters, Missouri, United States

Site Status

Rochester Clinical Research, LLC

Rochester, New York, United States

Site Status

Accellacare - Wilmington

Wilmington, North Carolina, United States

Site Status

AMR Clinical

Norman, Oklahoma, United States

Site Status

Cornerstone Nutrition and Diabetes

Norman, Oklahoma, United States

Site Status

Capital Area Research, LLC

Camp Hill, Pennsylvania, United States

Site Status

Elligo Clinical Research Center

Austin, Texas, United States

Site Status

Texas Diabetes & Endocrinology, P.A.

Austin, Texas, United States

Site Status

Velocity Clinical Research, Dallas

Dallas, Texas, United States

Site Status

UT Southwestern Medical Center

Dallas, Texas, United States

Site Status

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Site Status

Chrysalis Clinical Research

St. George, Utah, United States

Site Status

Southwest Internal Medicine, PC

St. George, Utah, United States

Site Status

Selma Medical Associates

Winchester, Virginia, United States

Site Status

Ocean West Research Clinic

Surrey, British Columbia, Canada

Site Status

Dawson Clinical Research Inc.

Guelph, Ontario, Canada

Site Status

The Wharton Medical Clinic Clinical Trials Inc.

Hamilton, Ontario, Canada

Site Status

Milestone Research Inc.

London, Ontario, Canada

Site Status

Canadian Phase Onward

Toronto, Ontario, Canada

Site Status

Centrum Zdrowia Metabolicznego Pawel Bogdanski

Poznan, Greater Poland Voivodeship, Poland

Site Status

Medicome Sp. z o. o.

Oświęcim, Lesser Poland Voivodeship, Poland

Site Status

Ekamed

Lublin, Lublin Voivodeship, Poland

Site Status

Centrum Badan Klinicznych PI-House sp. z o.o.

Gdansk, Pomeranian Voivodeship, Poland

Site Status

Centrum Medyczne Pratia Gdynia

Gdynia, Pomeranian Voivodeship, Poland

Site Status

Countries

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United States Canada Poland

Related Links

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https://pmiform.com/clinical-trial-info-request?StudyID=C5541010

To obtain contact information for a study center near you, click here.

Other Identifiers

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2024-513679-42-00

Identifier Type: REGISTRY

Identifier Source: secondary_id

C5541010

Identifier Type: -

Identifier Source: org_study_id

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