Influence of Beverage Choice on Hydration Status Cognition and Learning in Children

NCT ID: NCT06711926

Last Updated: 2025-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-26

Study Completion Date

2024-12-17

Brief Summary

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The main aim of this clinical trial is to compare the beverage hydration index of three different beverages in primary school-aged children.The Beverage Hydration Index (BHI), compares the hydration value of beverages against plain water. This study will explore the fluid retention capabilities of semi-skimmed milk, milk permeate, and water.

This study will also investigate:

* Identify the most effective beverage for hydration and the potential cognitive and mood benefits.
* To test if these beverages have any effect on gastric emptying
* To test if these beverages have any effect on appetite.
* To test the acceptability and palpability of semi-skimmed milk, milk permeate, and water in primary school-aged children.

Participants will:

* Take part in three study days (one for each beverage)
* Study day will take part between 9:00AM-12:30PM
* Participants will also record their food and fluid consumption the day before and consume a standardised breakfast before each trial.
* The beverage hydration index will be calculated as the mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
* Blood and urine samples will be taken to measure hydration
* Breath samples will be taken for gastric emptying rate
* COMPASS (Computerised Mental Performance Assessment System), fNIRS (Functional Near Infrared Spectroscopy) and visual analogue scales (VAS) measures will be obtained to assess cognition/mood
* An ad libitum pasta meal will be consumed after the trial to measure appetite, along with blood glucose and GLP-1 and further VAS to measure self reported hunger and fullness.
* A focus group will be held following completion of all three beverage trials, to gather participants opinion of each drink.

Detailed Description

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Conditions

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Dehydration in Children Thirst Beverage Hydration Index

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomised, crossover study.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants
Test beverages were presented to the participant in a dark bottle, and were not told which beverage they were consuming for each trial.

Study Groups

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Experimental: Beverage 1

Distilled water

Group Type EXPERIMENTAL

Distilled water

Intervention Type OTHER

Participants will receive 600ml distilled water with a strawberry flavour, in four equal aliquots across 30 minutes (150ml every 7.5minutes)

Experimental: Beverage 2

Semi skimmed milk

Group Type EXPERIMENTAL

Semi-skimmed milk

Intervention Type OTHER

Participants will receive \~600ml semi-skimmed milk with a strawberry flavour in four equal aliquots across 30minutes (150ml every 7.5minutes).

Experimental: Beverage 3

Whey permeate

Group Type EXPERIMENTAL

Whey permeate

Intervention Type OTHER

Participants will receive \~600ml whey permeate (30g sachet, rehydrated with distilled water)with strawberry flavour in four equal aliquots across 30minutes (150ml every 7.5minutes).

Interventions

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Distilled water

Participants will receive 600ml distilled water with a strawberry flavour, in four equal aliquots across 30 minutes (150ml every 7.5minutes)

Intervention Type OTHER

Semi-skimmed milk

Participants will receive \~600ml semi-skimmed milk with a strawberry flavour in four equal aliquots across 30minutes (150ml every 7.5minutes).

Intervention Type OTHER

Whey permeate

Participants will receive \~600ml whey permeate (30g sachet, rehydrated with distilled water)with strawberry flavour in four equal aliquots across 30minutes (150ml every 7.5minutes).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged between 9-11
* Healthy

Exclusion Criteria

* Psychiatric, neurological or mental disorder.
* Children with any morbidity that might influence hydration status (i.e., renal/cardiovascular/metabolic disease), blood-borne illness, or if they were taking any medications that may impact fluid balance.
* Children that are lactose intolerant
* Children that have any food allergies
Minimum Eligible Age

9 Years

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Surrey

OTHER

Sponsor Role collaborator

Northumbria University

OTHER

Sponsor Role lead

Responsible Party

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Catrin Roberts

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Catrin Roberts, PhD

Role: PRINCIPAL_INVESTIGATOR

Northumbria University

Locations

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Northumbria University

Newcastle upon Tyne, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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NorthumbriaU(CR/PR)

Identifier Type: -

Identifier Source: org_study_id

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