Mechanical Thrombectomy in the Middle East and North Africa: Interim Results from the MEMENTO Registry

NCT ID: NCT06702787

Last Updated: 2024-11-25

Basic Information

• Recruitment Status: ENROLLING_BY_INVITATION
• Total Enrollment: 1500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-11
• Study Completion Date: 2025-09-11

Brief Summary

The MEMENTO (MEchanical thrMobectomy NETwork for MENA TOgether) Registry is a multicenter, prospective observational study aiming to evaluate the effectiveness, safety, and cost-effectiveness of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) due to large vessel occlusions (LVO) in the Middle East and North Africa (MENA) region. This interim analysis reports on the first 499 patients enrolled, assessing clinical outcomes, procedural details, and economic implications.

Detailed Description

Detailed Description Stroke is a leading cause of morbidity and mortality worldwide, with a significant burden in the MENA region due to limited access to advanced stroke care therapies like mechanical thrombectomy (MT). The MEMENTO Registry seeks to collect real-world data on MT practices, outcomes, and accessibility in the MENA region to inform clinical practice and policy. The study includes AIS patients who underwent MT for confirmed LVO or medium vessel occlusion (MeVO), with or without prior intravenous thrombolysis (IV tPA), regardless of age, baseline NIHSS score, or time from symptom onset.

Data collected encompass demographics, clinical characteristics, imaging findings, procedural details, outcomes at discharge and follow-up, complications, and a cost-effectiveness analysis comparing MT to standard medical care (SMC). The primary outcome is functional independence at 90 days post-procedure, defined as a modified Rankin Scale (mRS) score of 0-2.

Conditions

Stroke; Stroke Acute; Endovascular Procedures; Large Vessel Occlusion

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

Adults aged 18 years and older (no upper age limit). Diagnosed with acute ischemic stroke due to confirmed large vessel occlusion (LVO) or medium vessel occlusion (MeVO).

Underwent mechanical thrombectomy (MT) with or without prior intravenous thrombolysis (IV tPA).

Pre-stroke modified Rankin Scale (mRS) score of 0-5. Consent to participate in the registry (by patient or legal representative).

Exclusion Criteria

Absence of confirmed LVO or MeVO. Pre-stroke mRS score of 6. Known severe comorbid conditions precluding MT. Inability to obtain informed consent. Patients not treated with MT.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Middle East North Africa Stroke and Interventional Neurotherapies Organization

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

ossama yassin MANSOUR, MD, PhD,

Role: PRINCIPAL_INVESTIGATOR

Alexandria University

farouk Hassan, MD,Phd

Role: PRINCIPAL_INVESTIGATOR

cairo university, Egypt

Atila Oscan Ozdimar, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Eskisehir Osmangazi University

Syed Irteza Hussain, MD

Role: PRINCIPAL_INVESTIGATOR

Cleveland Clinic Abu Dhabi

Faisal Alghamdi, MD

Role: PRINCIPAL_INVESTIGATOR

King Abdullah Medical City

Nadia Hammami, MD

Role: PRINCIPAL_INVESTIGATOR

institut National de Neurologie

Locations

Alexandria University Stroke network

Alexandria, Alexandria Governorate, Egypt

Countries

Egypt

Other Identifiers

MENASINO1002

Identifier Type: -

Identifier Source: org_study_id