Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients
NCT ID: NCT06691399
Last Updated: 2024-11-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2024-10-01
2025-06-01
Brief Summary
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Detailed Description
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Nosocomial pneumonia (NP) was defined as an infection of the lower respiratory tract that does not exist at the time of admission and does not have an incubation period of infection but occurs 48 hours after admission. The most important cause for the development of nosocomial pneumonia is the oral environment. The oral cavity of ICU patients is an important reservoir for bacteria and provides a habitat for microorganisms that can lead to nosocomial pneumonia. Patients in ICUs acquire pneumonia by aspirating oral bacteria that have been colonized in the oral cavity into the lower respiratory tract. Due to advanced age, limited mobility, illness, and cognitive dysfunction, patients in ICUs often have difficulty maintaining oral hygiene by themselves.
Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations. Therefore, strategies to eliminate respiratory pathogens from the oral cavity may improve oral hygiene and decrease the development of nosocomial pneumonia. The aim of the present study is to assess value of preventive strategy using chlorhexidine for oral care among non-intubated COPD patients admitted to ICU upon incidence of nosocomial pneumonia.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Routine oral care (Group 1)
Group (1) will receive routine oral care twice daily with gauze for cleansing and tooth brushing
Oral care
Oral care done twice daily with chlorhexidine oral care solution (concentration 1.2%)
Chlorhexidine oral care
Group (1) will receive routine oral care twice daily with gauze for cleansing and tooth brushing plus oral care with chlorohexidine solution (concentration 1.2%)
Oral care
Oral care done twice daily with chlorhexidine oral care solution (concentration 1.2%)
Interventions
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Oral care
Oral care done twice daily with chlorhexidine oral care solution (concentration 1.2%)
Eligibility Criteria
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Inclusion Criteria
* admitted to ICU with acute exacerbation
* need for noninvasive ventilatory support including noninvasive ventilation anf high flow nasal cannula
Exclusion Criteria
* End stage organ failure (Heart Failure, Liver cell failure and/or Renal failure
18 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Waleed Gamal Elddin Khaleel
Assistant Professor of Chest Diseases
Principal Investigators
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Waleed MD Gamal Elddin Khaleel, Ass. Prof.
Role: PRINCIPAL_INVESTIGATOR
Assiut University
Locations
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Faculty of Medicine, Assiut University
Asyut, , Egypt
Countries
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Central Contacts
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Facility Contacts
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References
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Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K; EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009 Dec 2;302(21):2323-9. doi: 10.1001/jama.2009.1754.
Vilela MC, Ferreira GZ, Santos PS, Rezende NP. Oral care and nosocomial pneumonia: a systematic review. Einstein (Sao Paulo). 2015 Apr-Jun;13(2):290-6. doi: 10.1590/S1679-45082015RW2980. Epub 2015 May 1.
Other Identifiers
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SOD2024
Identifier Type: -
Identifier Source: org_study_id
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