Vitamin D Metabolites as Biomarkers for the Identification of Kidney Injury in Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

46 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-12-02

Study Completion Date

2026-12-31

Brief Summary

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The investigators will be measuring vitamin D metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine. The investigators will include 20 patients in each of the following 3 groups based on serum creatinine measured within 28-days of surgery: 1) normal kidney function (eGFR \> 60 mL/min, n=20), 2) moderate impaired kidney function, eGFR between 30 and 60 mL/min (n=20) and 3) severe kidney dysfunction eGFR \< 30 mL/min (n=20).

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Detailed Description

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Conditions

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Acute Kidney Injuries Chronic Renal Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* ≥ 18 years
* Patients undergoing cardiac surgery
* Serum Creatinine measured with 28 days of surgery

Exclusion Criteria

* Exogeneous calcitriol (1,25(OH)2D3) intake
* History of parathyroidectomy
* Patients with liver or kidney cancer
* Patients with liver disease (e.g. liver failure, cirrhosis)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No