Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

NCT ID: NCT06687187

Last Updated: 2024-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-12-01

Study Completion Date

2024-05-01

Brief Summary

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A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.

Detailed Description

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Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.

Conditions

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Gastric Reflux

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group I

received neostigmine 1 mg

Neostigmine

Intervention Type DRUG

two groups (Group I, n= 41) and (Group II, n= 43) received varying doses of neostigmine (1 mg and 2 mg respectively

Group II

received neostigmine 2 mg

Neostigmine

Intervention Type DRUG

two groups (Group I, n= 41) and (Group II, n= 43) received varying doses of neostigmine (1 mg and 2 mg respectively

Group III

received normal saline

No interventions assigned to this group

Interventions

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Neostigmine

two groups (Group I, n= 41) and (Group II, n= 43) received varying doses of neostigmine (1 mg and 2 mg respectively

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients with a GRV \>120ml

Exclusion Criteria

* Patients exhibiting new-onset arrhythmias or heart block
* hypotension (systolic blood pressure less than 60 mmHg)
* experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
* patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
* patients with electrolyte imbalance
* pregnant patients,
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zulekha Hospitals

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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abdalla e hassan, lecturer

Role: PRINCIPAL_INVESTIGATOR

lecturer

Locations

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Al-Azhar faculty of medicine

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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382/46

Identifier Type: -

Identifier Source: org_study_id

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