A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56
NCT ID: NCT06668064
Last Updated: 2026-01-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
PHASE3
400 participants
INTERVENTIONAL
2024-10-22
2027-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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EYP-1901 2686 µg
EYP-1901
EYP-1901
Intravitreal Injection
Aflibercept
Aflibercept (2.0 mg)
Intravitreal Injection
Interventions
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EYP-1901
Intravitreal Injection
Aflibercept (2.0 mg)
Intravitreal Injection
Eligibility Criteria
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Inclusion Criteria
* Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
* For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.
Exclusion Criteria
* BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.
50 Years
ALL
No
Sponsors
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EyePoint Pharmaceuticals, Inc.
INDUSTRY
Responsible Party
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Locations
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Retinal Research Institute, LLC
Phoenix, Arizona, United States
Retina Partners of Northwest Arkansas
Springdale, Arkansas, United States
California Retina Consultants
Bakersfield, California, United States
Retina Vitreous Associates Medical Group
Beverly Hills, California, United States
Macula and Retina Institute
Glendale, California, United States
Gavin Herbert Eye Institute
Irvine, California, United States
Retina Consultants San Diego
Poway, California, United States
Retina Consultants of Southern California
Redlands, California, United States
Retinal Consultants Medical Group
Sacramento, California, United States
West Coast Retina Medical Group
San Francisco, California, United States
Bay Area Retina Associates
Walnut Creek, California, United States
American Institute of Research
Whittier, California, United States
RSC Research, PLLC
Denver, Colorado, United States
Eye Center of Northern Colorado, PC
Fort Collins, Colorado, United States
Advanced Vision Institute
Longmont, Colorado, United States
Connecticut Eye Consultants, P.C.
Danbury, Connecticut, United States
SightSera Clinical Research LLC
Greenwich, Connecticut, United States
Retina Group of New England, PC
Waterford, Connecticut, United States
Advanced Research, LLC
Deerfield Beach, Florida, United States
Vitreo Retinal Associates
Gainesville, Florida, United States
Florida Retina Consultants
Lakeland, Florida, United States
Florida Retina Institute
Orlando, Florida, United States
Retina Specialty Institute
Pensacola, Florida, United States
Eye Associates of Pinellas
Pinellas Park, Florida, United States
Retina Group of Florida
Sarasota, Florida, United States
MedEye Associates
South Miami, Florida, United States
Retina Specialists of Tampa
Tampa, Florida, United States
Retina Vitreous Associates of Florida
Tampa, Florida, United States
Center for Retina & Macular Disease
Winter Haven, Florida, United States
Gerogia Retina
Marietta, Georgia, United States
Retina Consultants of Hawaii
‘Aiea, Hawaii, United States
Retina Associates
Elmhurst, Illinois, United States
University Retina and Macula Associates
Lemont, Illinois, United States
Midwest Eye Institute
Carmel, Indiana, United States
Retina Associates LLC
Lenexa, Kansas, United States
Maine Eye Center
Portland, Maine, United States
The Retina Care Center
Baltimore, Maryland, United States
Retina Groups of Washington
Chevy Chase, Maryland, United States
Cumberland Valley Retina Consultants
Hagerstown, Maryland, United States
Retina Specialists
Towson, Maryland, United States
Ophthalmic Consultants of Boston OCB - Boston
Boston, Massachusetts, United States
New England Retina Consultants
Springfield, Massachusetts, United States
Retina Associates of Michigan
Grand Blanc, Michigan, United States
Foundation for Vision Research
Grand Rapids, Michigan, United States
Deep Blue Retina Clinical Research PLLC
Southaven, Mississippi, United States
The Retina Institute
St Louis, Missouri, United States
Sierra Eye Associates
Reno, Nevada, United States
NJ Retina
Teaneck, New Jersey, United States
NJ Retina
Toms River, New Jersey, United States
Vision Research Center at Eye Associates of New Mexico
Albuquerque, New Mexico, United States
Retina Vitreous Surgeons of CNY, PC
Liverpool, New York, United States
Retina Associates of Western NY, PC
Rochester, New York, United States
Retina Consultants PLLC
Slingerlands, New York, United States
Western Carolina Retinal Associates, PA
Asheville, North Carolina, United States
Cape Fear Retinal Associates, PC
Wilmington, North Carolina, United States
Piedmont Retina Specialists, P.A. - Winston-Salem Office
Winston-Salem, North Carolina, United States
Midwest Retina, Inc.
Dublin, Ohio, United States
Tulsa Retina Consultant
Tulsa, Oklahoma, United States
Verum Research LLC
Eugene, Oregon, United States
Erie Retina Research
Erie, Pennsylvania, United States
Eye Care Specialists - Kingston Location
Kingston, Pennsylvania, United States
Retina Consultants
Charleston, South Carolina, United States
Palmetto Retina Center
Florence, South Carolina, United States
Retina Consultants of Carolina P.A
Greenville, South Carolina, United States
Charles Retina Institute
Germantown, Tennessee, United States
Retina Research Institute of Texas Integrated Clinical Research
Abilene, Texas, United States
Retina and Vitreous of Texas
Bellaire, Texas, United States
Retina Consultants of Texas (Retina Consultants of Houston) - Woodlands
Bellaire, Texas, United States
Texas Retina Associates
Dallas, Texas, United States
Houston Eye Associates
Houston, Texas, United States
Texas Retina Associates
Plano, Texas, United States
San Antonio Eye Center
San Antonio, Texas, United States
Retinal Consultants of Texas
San Antonio, Texas, United States
Retina Center of Texas
Southlake, Texas, United States
Retina Consultants of Texas
The Woodlands, Texas, United States
Tyler Retina Consultants
Tyler, Texas, United States
Strategic Clinical Research Group, LLC
Willow Park, Texas, United States
Retina Associates of Utah
Salt Lake City, Utah, United States
Rocky Mountain Retina Consultants
Salt Lake City, Utah, United States
Salt Lake Retina
West Jordan, Utah, United States
The Retina Group of Washington
Fairfax, Virginia, United States
Piedmont Eye Center
Lynchburg, Virginia, United States
Retina Associates, P.C.
Winchester, Virginia, United States
University of Wisconsin School of Medicine and Public Health (UWSMPH)
Madison, Wisconsin, United States
Countries
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Other Identifiers
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EYP-1901-301
Identifier Type: -
Identifier Source: org_study_id
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