A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring

NCT ID: NCT06660342

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

728 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-15

Study Completion Date

2034-09-30

Brief Summary

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The main objective of the study is to compare the maternal, fetal, and infant outcomes of pregnant women who are exposed to vonoprazan during pregnancy with outcomes of an internal comparison cohort of pregnant women who are unexposed to vonoprazan during pregnancy but who may be exposed to other products for the treatment of conditions for which vonoprazan may be prescribed.

Detailed Description

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Conditions

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Erosive Esophagitis Heartburn Symptomatic Non-erosive Gastroesophageal Reflux Disease Helicobacter Pylori Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Exposed Cohort

Pregnant women who are exposed to vonoprazan during pregnancy.

Vonoprazan

Intervention Type DRUG

Oral tablet.

Unexposed Cohort

Pregnant women who are not exposed to vonoprazan during pregnancy but who may be exposed to other products for the treatment of conditions for which vonoprazan may be prescribed.

No interventions assigned to this group

Interventions

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Vonoprazan

Oral tablet.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women 15 to 50 years of age.
* Currently or recently pregnant.
* Consent to participate.
* Authorization for her health care provider(s) (HCP\[s\]) to provide data to the registry.
* Exposed cohort: Exposure to at least one dose of vonoprazan during pregnancy.
* Unexposed cohort: Unexposed to vonoprazan and diagnosis of any condition for which vonoprazan may be prescribed.

Exclusion Criteria

* Occurrence of pregnancy outcome prior to first contact with the virtual research coordination center (VRCC) (retrospectively enrolled).
* Exposure to known tetratogens and/or investigational medications during pregnancy.
* Lost to follow-up.
Minimum Eligible Age

15 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Phathom Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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PPD

Wilmington, North Carolina, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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VOQUEZNA Pregnancy Registry

Role: CONTACT

1-866-609-1612

Other Identifiers

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VONO-402

Identifier Type: -

Identifier Source: org_study_id

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