Interventions for Promoting Kidney Transplant Empowerment

NCT ID: NCT06655857

Last Updated: 2025-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-05

Study Completion Date

2026-03-31

Brief Summary

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This is a cluster randomized controlled clinical trial evaluating the effect of community health workers (CHWs) and provider education on kidney transplant (KTx) waitlisting compared to usual care (waitlist control). CKD/HD providers will be randomized to intervention or control, and all patients with the same providers will be in the same randomization group. CHWs will address unmet social needs and patient symptoms through evaluations and linkage to clinical and community services. Intervention providers will receive education, which will include training on working with CHWs, reducing bias in clinical decision-making, and increasing affirming/reducing stigmatizing language in electronic health records (EHRs).

Detailed Description

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Conditions

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Kidney Transplant Waitlisting

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Community Health Worker and Intervention Providers-Assisted Kidney Transplant Support

Participants will receive assignment to a community health worker who will educate them on the kidney transplant process, assist them through the kidney transplant process and connect them with any necessary social services.

Group Type OTHER

Community Health Worker Assistance

Intervention Type OTHER

Community health worker will address unmet social needs and participant symptoms through evaluations and intake to clinical and community services

Intervention Providers

Intervention Type OTHER

Intervention providers will receive education, which will include training on working with CHWs, reducing bias in clinical decision-making, and increasing affirming/reducing stigmatizing language in electronic health records (EHRs).

Usual Care

Participants will receive usual care and at the end of the study will receive education, and work with CHWs in a more limited capacity. Control clinicians will receive the education intervention.

Group Type OTHER

Usual Care

Intervention Type OTHER

Participants are provided care as usual. Clinicians (CKD, HD, KTx) will educate participants on the kidney transplant process. Clinician will receive the education intervention to provide participants at study end.

Community Health Worker Assistance

Intervention Type OTHER

Community health worker will address unmet social needs and participant symptoms through evaluations and intake to clinical and community services

Intervention Providers

Intervention Type OTHER

Intervention providers will receive education, which will include training on working with CHWs, reducing bias in clinical decision-making, and increasing affirming/reducing stigmatizing language in electronic health records (EHRs).

Interventions

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Usual Care

Participants are provided care as usual. Clinicians (CKD, HD, KTx) will educate participants on the kidney transplant process. Clinician will receive the education intervention to provide participants at study end.

Intervention Type OTHER

Community Health Worker Assistance

Community health worker will address unmet social needs and participant symptoms through evaluations and intake to clinical and community services

Intervention Type OTHER

Intervention Providers

Intervention providers will receive education, which will include training on working with CHWs, reducing bias in clinical decision-making, and increasing affirming/reducing stigmatizing language in electronic health records (EHRs).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient inclusion:

* Provision of signed and dated informed consent from the patient.
* Stated willingness to comply with all study procedures and availability for the duration of the study.
* Age 18 - 75 years
* eGFR≤20 mL/min/1.73m2 or on maintenance in-center HD.
* Receive kidney care at Mount Sinai, Einstein, Bellevue Hospital, NYU, or hemodialysis at a participating HD Center.
* Community dwelling (i.e., not in a nursing home, currently incarcerated).
* Speak English and/or Spanish.
* Provider Inclusion:

* Provision of signed and dated informed consent from the nephrologist.
* Stated willingness to comply with all study procedures and availability for the duration of the study.

Exclusion Criteria

* Patient Exclusion:

* Absolute contraindications to KTx:

* Self-reported or documented diagnosis of dementia, or inability to understand the study and complete informed consent. When the participant's understanding is unclear, the CRC will use a modified MOCA screener to determine eligibility.
* Active malignancy (excluding local non-melanoma skin cancer, renal cell carcinoma \<5 cm, early thyroid cancer, and prostate cancer GS≤6).
* Pregnancy (can be re-evaluated post-delivery).
* Active infection. Patients excluded due to active infection will be evaluated at 30 days or after completing full treatment (whichever is later) to determine eligibility. Examples of active infection include:

* Positive cultures or radiographic evidence of infection
* Infected intravascular devices, such as tunneled catheters and pacemakers
* Active histoplasmosis, cryptococcosis, tuberculosis (TB), and nontuberculous mycobacteria
* Previously evaluated by KTx and not listed for specific medical reasons.
* Patients previously evaluated and not listed will be carefully reviewed by site PI for eligibility
* Already listed for KTx.
* Patients on other types of dialysis other than in-center hemodialysis.
* Self-identify as already engaged with a CHW at participating sites to address unmet social needs.
* Planning to move out of the greater NY area in the next 1 year.
* Provider Exclusion:

* Planning to leave their respective institutions in the next 1 year
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

Icahn School of Medicine at Mount Sinai

OTHER

Sponsor Role lead

Responsible Party

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Lili Chan

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lili Chan

Role: PRINCIPAL_INVESTIGATOR

Ichan School of Medicine at Mount Sinai Hospital

Locations

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NYU Langone Health

New York, New York, United States

Site Status NOT_YET_RECRUITING

Mount Sinai Hospital

New York, New York, United States

Site Status RECRUITING

Montefiore Einstein

The Bronx, New York, United States

Site Status NOT_YET_RECRUITING

Countries

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United States

Central Contacts

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Lili Chan

Role: CONTACT

929-618-0350

Facility Contacts

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Michal Melamed

Role: primary

Lili Chan

Role: primary

Sabrina Clermont

Role: backup

Tanya Johns

Role: primary

Other Identifiers

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U01DK137259

Identifier Type: NIH

Identifier Source: secondary_id

View Link

GCO 22-1921

Identifier Type: -

Identifier Source: org_study_id

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