Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC

NCT ID: NCT06648525

Last Updated: 2024-10-18

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 68 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-10-31
• Study Completion Date: 2028-04-30

Brief Summary

This is a multicenter, open label, randomized, two-arm clinical study to observe and evaluate the efficacy and safety of adebrelimab combined with irinotecan liposomes, 5-fluorouracil, calcium folinate ± lenvatinib as first-line treatment for advanced intrahepatic cholangiocarcinoma (ICC).

Detailed Description

This study plans to recruit 68 patients with unresectable ICC who have not received prior systematic treatment. The patients will be randomly divided into two groups. Group A: patients will receive adebrelimab+irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib; Group B: patients will receive treatment with adebrelimab+irinotecan liposomes+5-fluorouracil+calcium folinate. The combination of irinotecan liposomes+5-fluorouracil+calcium folinate will be used 9 times (Q2W), and adebrelimab ± lenvatinib will be used until disease progression or medication for 2 years.

Conditions

Intrahepatic Cholangiocarcinoma (Icc)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Group A: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib

Adebrelimab in combination with Irinotecan liposomes, 5-fluorouracil, calcium folinate and lenvatinib

Group Type: EXPERIMENTAL

Adebrelimab

Intervention Type: DRUG

Adebrelimab, IV

Irinotecan liposomes

Intervention Type: DRUG

Irinotecan liposomes, IV

Lenvatinib

Intervention Type: DRUG

Lenvatinib, po

5-Fluorouracil (5-FU)

Intervention Type: DRUG

5-Fluorouracil (5-FU), IV

Calcium Folinate

Intervention Type: DRUG

Calcium folinate, IV

Group B: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate

Adebrelimab in combination with Irinotecan liposomes, 5-fluorouracil and calcium folinate

Group Type: EXPERIMENTAL

Adebrelimab

Intervention Type: DRUG

Adebrelimab, IV

Irinotecan liposomes

Intervention Type: DRUG

Irinotecan liposomes, IV

5-Fluorouracil (5-FU)

Intervention Type: DRUG

5-Fluorouracil (5-FU), IV

Calcium Folinate

Intervention Type: DRUG

Calcium folinate, IV

Interventions

Adebrelimab

Adebrelimab, IV

Intervention Type: DRUG

Irinotecan liposomes

Irinotecan liposomes, IV

Intervention Type: DRUG

Lenvatinib

Lenvatinib, po

Intervention Type: DRUG

5-Fluorouracil (5-FU)

5-Fluorouracil (5-FU), IV

Intervention Type: DRUG

Calcium Folinate

Calcium folinate, IV

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Age: 18 to 75 years old, male or female not limited;

2. Histologically confirmed unresectable locally advanced or metastatic intrahepatic cholangiocarcinoma with measurable tumor lesions (meeting RECIST 1.1 criteria);

3. Have not received systemic anti-tumor treatment in the past;

5. ECOG PS：0-1；

6. Expected survival period ≥ 3 months;

7. The main organ functions are normal, which meets the following criteria:

1) Blood routine examination (without blood transfusion or correction with hematopoietic stimulating factor drugs within 14 days): Hemoglobin (Hb) ≥ 85 g/L; Absolute neutrophil count (ANC) ≥ 1.5 × 109/L; Platelet count (PLT) ≥ 80 × 109/L; 2) Biochemical examination: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 5 × ULN; Serum total bilirubin (TBIL) ≤ 3 × ULN; Serum creatinine (Cr) ≤ 1.5 × ULN or creatinine clearance rate ≥ 50ml/min; 3) Coagulation function: Activated partial thromboplastin time (APTT), international normalized ratio (INR), prothrombin time (PT) ≤ 1.5 × ULN; 4) Doppler ultrasound evaluation: Left ventricular ejection fraction (LVEF) ≥ 50%; 8. Women of childbearing age must undergo a negative pregnancy test (β HCG) before starting treatment, and women and men of childbearing age (who have sexual relations with women of childbearing age) must agree to continuously use effective contraceptive measures during the treatment period and for 6 months after the last treatment dose; 9. Patients with a history of hepatitis B and C can be included in the study, but active hepatitis B patients must start antiviral therapy before starting the study treatment; 10. Participants voluntarily join the study and sign an informed consent form.

Exclusion Criteria

1. Pregnant or lactating women, or those who have the ability to conceive but refuse to take contraceptive measures;

2. History of other malignant tumors within the past 5 years, excluding cervical carcinoma in situ or squamous cell carcinoma of the skin that has been adequately treated, or basal cell carcinoma of the skin that has been largely controlled;

3. Merge other serious uncontrolled diseases (such as individuals with a history of difficult to control mental illness or severe intellectual or cognitive impairment; severe heart failure, angina pectoris, myocardial infarction, arrhythmia, etc.);

4. Pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, and severe impairment of lung function;

5. Suffering from active, known or suspected autoimmune diseases. Subjects with hypothyroidism who only require hormone replacement therapy and those with skin diseases that do not require systemic treatment may be included;

6. Easy to bleed, at risk of massive hemoptysis, and with a history of significant coagulation dysfunction;

7. Suffering from hypertension and unable to achieve good control with antihypertensive medication (systolic blood pressure ≥ 140mmHg or diastolic blood pressure ≥ 90mmHg);

8. History of immunodeficiency, including HIV testing positive, having other acquired or congenital immunodeficiency diseases, or having a history of organ transplantation and allogeneic bone marrow transplantation;

9. Severe active infections requiring intravenous antibiotic treatment occur during the screening period;

10. Individuals with multiple factors that affect oral medication (such as inability to swallow, post gastrointestinal resection, chronic diarrhea, and intestinal obstruction);

11. Individuals who are allergic to the experimental drug;

12. Patients who cannot comply with the trial protocol or cooperate with follow-up;

13. The researchers believe that participants should not participate in this experiment.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Harbin Medical University

OTHER

Sponsor Role: lead

Responsible Party

Zhiwei Li

Head of the gastroenterology ward

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Harbin Medical University

Harbin, Heilongjiang, China

Countries

China

Central Contacts

Zhiwei Li, MD

Role: CONTACT

lzhw0451@163.com

86+15004683651

Facility Contacts

Zhiwei Li, MD

Role: primary

lzhw0451@163.com

86+15004683651

Other Identifiers

MA-ICC-II-006

Identifier Type: -

Identifier Source: org_study_id