Combined Effect of tDCS and Motor or Cognitive Activity in Patients With Alzheimer's Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-01

Study Completion Date

2019-12-31

Brief Summary

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The goal of this clinical trial is to evaluate the effectiveness of combining tDCS with motor or cognitive activities on cognitive functions in patients with AD. Second aim is to investigate if tDCS has a different impact if it is combined with motor or cognitive activities.

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Detailed Description

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Conditions

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Alzheimer Disease (AD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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CogS

The participants underwent cognitive treatment while receiving sham tDCS stimulation.

Group Type SHAM_COMPARATOR

Sham tDCS

Intervention Type DEVICE

In addition to Sham tDCS stimulation, participants simultaneously underwent motor or cognitive therapy, depending on their assigned group.

MotS

The participants underwent motor treatment while receiving sham tDCS stimulation

Group Type SHAM_COMPARATOR

Sham tDCS

Intervention Type DEVICE

In addition to Sham tDCS stimulation, participants simultaneously underwent motor or cognitive therapy, depending on their assigned group.

CogA

The participants underwent cognitive treatment while simultaneously receiving anodal stimulation with tDCS.

Group Type EXPERIMENTAL

Anodal tDCS

Intervention Type DEVICE

In addition to anodal tDCS stimulation, participants simultaneously underwent motor or cognitive therapy, depending on their assigned group.

MotA

The participants underwent motor treatment while simultaneously receiving anodal stimulation with tDCS.

Group Type EXPERIMENTAL

Anodal tDCS

Intervention Type DEVICE

In addition to anodal tDCS stimulation, participants simultaneously underwent motor or cognitive therapy, depending on their assigned group.

Interventions

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Anodal tDCS

In addition to anodal tDCS stimulation, participants simultaneously underwent motor or cognitive therapy, depending on their assigned group.

Intervention Type DEVICE

Sham tDCS

In addition to Sham tDCS stimulation, participants simultaneously underwent motor or cognitive therapy, depending on their assigned group.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Mini Mental State Examination (MMSE) major or equal to 15;
* good level of compliance;
* acetylcholinesterase inhibitor treatment (e.g., donepezil, rivastigmine);
* no modifications of medication during the last four months.

Exclusion Criteria

* behavioral disorders (e.g., aggressiveness);
* alcohol abuse;
* orthopedic pathology with risk of falls to the ground;
* respiratory pathology;
* severe auditory or visual deficits uncorrected;
* history of epileptic fits;
* anti-epileptic medication;
* metallic body implants; pacemaker;
* psychiatric, neurologic, systemic or metabolic disorders.

Eligible Sex

ALL

Accepts Healthy Volunteers

No